Results 61 to 70 of about 1,914,304 (195)

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling.

open access: yesPLoS Genetics, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
Caroline Bivik   +5 more
doaj   +1 more source

Modelling delta-notch perturbations during zebrafish somitogenesis [PDF]

open access: yes, 2013
The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, R. E.   +8 more
core   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]

open access: yes, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

core   +2 more sources

A unifying approach to fatigue design in presence of defects and notches subject to uniaxial loading

open access: yesMATEC Web of Conferences, 2014
In the recent past, Atzori and Lazzarin proposed a diagram able to include the geometrical effects on the fatigue limit of defects, short cracks, long cracks and U-shaped notches of whatever severity.
Atzori Bruno   +2 more
doaj   +1 more source

Compact Electromagnetic Bandgap Structures for Notch Band in Ultra-Wideband Applications

open access: yes, 2010
This paper introduces a novel approach to create notch band filters in the front-end of ultra-wideband (UWB) communication systems based on electromagnetic bandgap (EBG) structures.
Jan Sykulski   +3 more
core   +1 more source

Notch sensitivity of polycarbonate and toughened polycarbonate

open access: yes, 2018
Notch sensitivity, the effect of a notch radius on the impact behavior of polycarbonate and rubber-toughened polycarbonate, is investigated by using a model based on the slip-lines field theory.
Kang, BI, Yang, JH, Park, CE, Cho, K
core   +1 more source

Molecular genetic analysis of a "sine oculis" enhancer and the "leventina" gene as a model system to study human macular degeneration in "Drosophila" [PDF]

open access: yes, 2004
The leventina gene as a model system to study human macular degeneration in Drosophila. Age-related macular degeneration (AMD) is one of the most frequent reasons for blindness of the elderly people and accounts for approximately 50% of registered ...
Pauli, Tobias Samuel
core   +1 more source

Detection of Onset, Systolic Peak and Dicrotic Notch in Arterial Blood Pressure Pulses

open access: yesMeasurement + Control, 2017
In this paper, we proposed an effective method for detecting fiducial points in arterial blood pressure pulses. An arterial blood pressure pulse normally consists of onset, systolic peak and dicrotic notch.
Omkar Singh, Ramesh Kumar Sunkaria
doaj   +1 more source

On the Notch Effect in Low Temperature Carburized Stainless Steel under Fatigue

open access: yesEPJ Web of Conferences, 2010
The present paper describes the fatigue behaviour of carburized notched AISI 316 austenitic stainless steel specimens. Rotary four point bending fatigue tests have been performed using carburized smooth specimens with two different values of surface ...
Minak G.
doaj   +1 more source

Notch as a Driver of Gastric Epithelial Cell ProliferationSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2017
The gastric epithelium is sustained by a population of stem cells that replenish the various mature epithelial lineages throughout adulthood. Regulation of stem and progenitor cell proliferation occurs via basic developmental signaling pathways ...
Elise S. Demitrack, Linda C. Samuelson
doaj   +1 more source

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