Results 41 to 50 of about 62,204 (160)

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

open access: yesKaohsiung Journal of Medical Sciences, 2019
Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj   +1 more source

Influence of as-built surface on fatigue strength and notch sensitivity of Ti6Al4V alloy produced by DMLS

open access: yesMATEC Web of Conferences, 2018
Direct Metal Laser Sintering (DMLS) is one of the additive manufacturing technologies involving a metal powder bed and a laser source to obtain components of complex geometry.
Nicoletto Gianni   +3 more
doaj   +1 more source

Cis-activation in the Notch signaling pathway

open access: yeseLife, 2019
The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling.
Nagarajan Nandagopal   +2 more
doaj   +1 more source

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling.

open access: yesPLoS Genetics, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
Caroline Bivik   +5 more
doaj   +1 more source

A unifying approach to fatigue design in presence of defects and notches subject to uniaxial loading

open access: yesMATEC Web of Conferences, 2014
In the recent past, Atzori and Lazzarin proposed a diagram able to include the geometrical effects on the fatigue limit of defects, short cracks, long cracks and U-shaped notches of whatever severity.
Atzori Bruno   +2 more
doaj   +1 more source

Detection of Onset, Systolic Peak and Dicrotic Notch in Arterial Blood Pressure Pulses

open access: yesMeasurement + Control, 2017
In this paper, we proposed an effective method for detecting fiducial points in arterial blood pressure pulses. An arterial blood pressure pulse normally consists of onset, systolic peak and dicrotic notch.
Omkar Singh, Ramesh Kumar Sunkaria
doaj   +1 more source

On the Notch Effect in Low Temperature Carburized Stainless Steel under Fatigue

open access: yesEPJ Web of Conferences, 2010
The present paper describes the fatigue behaviour of carburized notched AISI 316 austenitic stainless steel specimens. Rotary four point bending fatigue tests have been performed using carburized smooth specimens with two different values of surface ...
Minak G.
doaj   +1 more source

Notch as a Driver of Gastric Epithelial Cell ProliferationSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2017
The gastric epithelium is sustained by a population of stem cells that replenish the various mature epithelial lineages throughout adulthood. Regulation of stem and progenitor cell proliferation occurs via basic developmental signaling pathways ...
Elise S. Demitrack, Linda C. Samuelson
doaj   +1 more source

Ultrathin Platinum Film Hydrogen Sensors with a Twin-T Type Notch Filter Circuit

open access: yesSensors
In recent years, hydrogen energy has garnered attention as a potential solution for mitigating greenhouse gas emissions. However, concerns regarding the inherent risk of hydrogen gas leakage and potential explosions have necessitated the development of ...
Shoki Wakabayashi   +4 more
doaj   +1 more source

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells

open access: yesStem Cell Reports, 2017
Summary: Accumulating evidence suggests that cancer cells with stem cell-like phenotypes drive disease progression and therapeutic resistance in glioblastoma (GBM).
Yufang Ma   +9 more
doaj   +1 more source

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