Molecular Metabolism, 2016 Objective: As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed.
David P. Sparling +6 more
doaj +1 more source
Notch Signaling Regulates Muscle Stem Cell Homeostasis and Regeneration in a Teleost Fish
Frontiers in Cell and Developmental Biology, 2021 Muscle regeneration is mediated by the activity of resident muscle satellite cells (muSCs) that express Pax7. In mouse Notch signaling regulates muSCs during quiescence and promotes muSC proliferation in regeneration.
Sami H. A. Sultan +3 more
doaj +1 more source
NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]
, 2018 Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana +14 more
core +2 more sources
Study on Hydrogen Embrittlement Sensitivity of L245 Seamless Steel Pipe Under 4 MPa H2 Environment [PDF]
Cailiao Baohu, 2023 In order to investigate the hydrogen embrittlement sensitivity of the low-grade pipeline steel in medium-pressure hydrogen environment，the hydrogen embrittlement sensitivity of L245 steel in air environment and 4 MPa hydrogen environment was studied by ...
DU Peien, SONG Weichen, LIU Zhi, FU Guoqiang, LI Ba, WANG Bing, LIU Qingyou
doaj +1 more source
Endothelial Notch signaling controls insulin transport in muscle
EMBO Molecular Medicine, 2020 The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ‐specific manner ...
Sana S Hasan +19 more
doaj +1 more source
Fracture Mechanics Characterization of an AnisotropicGeomaterial [PDF]
, 2012 Argillites are considered worldwide as potential host rock for high level radioactive waste given the low permeability and strong adsorption potential.
Barpi, Fabrizio +4 more
core +1 more source
On the multiaxial fatigue assessment of complex three-dimensional stress concentrators [PDF]
, 2014 This paper assesses and quantifies the detrimental effects of complex tri-dimensional notches subjected to uniaxial and multiaxial fatigue loading. A number of experimental results taken from the technical literature and generated by testing specimens ...
ASKES, Harm +4 more
core +6 more sources
A microwave dielectric biosensor based on suspended distributed MEMS transmission lines [PDF]
, 2009 Design and characterization of a miniature microwave dielectric biosensor based on distributed microelectromechanical systems (MEMS) transmission lines (DMTL) is reported in this paper.
Li, Lijie +3 more
core +1 more source
Assessing the Notch Sensitivity of High Strength Wires
Latin American Journal of Solids and StructuresHigh strength wires, which have a poor notch sensitivity performance, are currently been used on many offshore applications where high stresses without yielding are demanded. To assess these wires notch sensitivity, an integrated approach was implemented.
Carlos Filipe Cardoso Bandeira +2 more
doaj +1 more source
Characterization of defect induced multilayer graphene [PDF]
, 2017 A study of oxygen plasma on multilayer graphene is done with different flow rates. This is to allow a controlled amount of defect fabricated on the graphene.
Abdullahb, Abu Hannifa +4 more
core +2 more sources