Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer. [PDF]
BiomedicinesMitka-Krysiak E +12 more
europepmc +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Mac-/Lactosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling. [PDF]
ElifeTang K +8 more
europepmc +1 more source
Advanced Science, EarlyView.A general fabricating strategy for arbitrary 3D organic mixed ionic‐electronic conductor architectures is reported using PEDOT:PSS microfiber building blocks. A water‐assisted self‐fusion process is successfully developed in which adhesion can be modulated as reversible (PSS‐rich) or irreversible (PEDOT‐rich) self‐fusion depending on the post‐treatment
Youngseok Kim +8 more
wiley +1 more source
Gene regulatory networks involved in activation of Notch signaling by AGEs in the pathogenesis of diabetic kidney disease. [PDF]
PLoS OneBaishya S +3 more
europepmc +1 more source
Advanced Science, EarlyView.We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu +8 more
wiley +1 more source
Comprehensive comparative analysis of the effects of temperature on the Notch signaling response in vivo. [PDF]
Biol OpenJohn NS, Tang KS, Urman MA, Lee C.
europepmc +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
The Notch signaling pathway in regulating bone and cartilage homeostasis: novel insights into the pathogenesis and therapeutics of osteoarthritis. [PDF]
Cell Commun SignalWang H, Li M, Wang X, Han J, Zhang XA.
europepmc +1 more source