Results 211 to 220 of about 133,611 (360)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Role of Notch signaling in corticalization. [PDF]

J Endocrinol Invest
Mazziotti G, Canalis E.
europepmc   +1 more source

Notch Signaling at Later Stages of NK Cell Development Enhances KIR Expression and Functional Maturation [PDF]

, 2014
Martin Felices, Dave Ankarlo, Todd Lenvik, Heather H. Nelson, Bruce R. Blazar, Michael R. Verneris, Jeffrey S. Miller   +6 more
openalex   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Jagged2a-Notch Signaling Mediates Cell Fate Choice in the Zebrafish Pronephric Duct

, 2007
Ming Ma, Yun‐Jin Jiang
openalex   +2 more sources

Correction: Development and Cancer: At the Crossroads of Nodal and Notch Signaling [PDF]

, 2009

openalex   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Targeting notch signaling to restore neural development and behavior in mouse models of ASD. [PDF]

Nat Commun
Hanno Y, Nakanishi M, Takase A, Nomura J, Tanaka M, Iida Y, Tanaka M, Hosokawa H, Ito M, Mikami K, Hozumi K, Miyoshi G, Takumi T, Iijima T.   +13 more
europepmc   +1 more source

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

Advanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang, Jinlei Jiang, Zhengting Wang, Shuqi Liu, Wei Wang, Xi Chen, Qirui Zhao, Xinyuan Cui, Cheng Zhou, Shengsheng Cui, Daxiang Cui   +10 more
wiley   +1 more source

Direct observation of Notch signaling-induced transcription hubs mediating gene-expression responses. [PDF]

Sci Adv
Santa-Cruz Mateos C, Roussos C, de Haro Arbona FJ, Falo-Sanjuan J, Bray S.   +4 more
europepmc   +1 more source