Results 231 to 240 of about 110,123 (264)

Notch Signaling in Osteoblasts

Science Signaling, 2008
Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation ...
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Notch Signaling in Solid Tumors

2010
In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer. The finding that activating Notch mutations are frequently found in patients suffering from acute lymphoblastic leukemia is one of the best
Koch, Ute, Radtke, Freddy
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Deciphering Notch signaling notch by notch

Cell Signaling, 2023
Lidia Borkiewicz, Adolfo Rivero-Müller
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Notch Signaling and Liver Cancer

2020
Interactions between liver cells are closely regulated by Notch signaling. Notch signaling has been reported clinically related to bile duct hypogenesis in Alagille syndrome, which is caused by mutations in the Jagged1 gene. Notch activation and hepatocarcinogenesis are closely associated since cancer signaling is affected by the development of liver ...
Kazunori, Kawaguchi, Shuichi, Kaneko
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Glycosylation regulates Notch signalling

Nature Reviews Molecular Cell Biology, 2003
Intracellular post-translational modifications such as phosphorylation and ubiquitylation have been well studied for their roles in regulating diverse signalling pathways, but we are only just beginning to understand how differential glycosylation is used to regulate intercellular signalling.
Nicola, Haines, Kenneth D, Irvine
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Notch Signaling in Leukemias and Lymphomas

Current Molecular Medicine, 2008
Aberrant Notch activation is linked to cancer since 1991 when mammalian Notch1 was first identified as part of the translocation t(7;9) in a subset of human T-cell acute lymphoblastic leukemias (T-ALL). Since then oncogenic Notch signaling has been found in many solid and hematopoietic neoplasms.
Franziska, Jundt, Rolf, Schwarzer, Bernd, Dörken   +2 more
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Biodiversity and Noncanonical Notch Signaling

2010
Early genetics in flies revealed that Notch is a complex pleiotropic locus. We now know that Notch is a receptor that plays prominent roles during development and functions locally in many tissues to instruct cell fate decisions. Drosophila has been an excellent model to identify genetically the elements that contribute to the canonical Notch signaling
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Notch signaling in pediatric malignancies

Current Oncology Reports, 2008
Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected.
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Notch Signaling and Breast Cancer

2012
It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer.
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Role of Notch signaling in neurovascular aging and Alzheimer’s disease

Seminars in Cell and Developmental Biology, 2021
Daniel Nation, Arunima Kapoor
exaly