Results 271 to 280 of about 190,719 (307)
Some of the next articles are maybe not open access.
Notch Signaling in Osteoblasts
Science Signaling, 2008Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation ...
openaire +2 more sources
Notch Signaling and Liver Cancer
2020Interactions between liver cells are closely regulated by Notch signaling. Notch signaling has been reported clinically related to bile duct hypogenesis in Alagille syndrome, which is caused by mutations in the Jagged1 gene. Notch activation and hepatocarcinogenesis are closely associated since cancer signaling is affected by the development of liver ...
Kazunori, Kawaguchi, Shuichi, Kaneko
openaire +2 more sources
2018
Discovered nearly a century ago, today, Notch is known to mediate several biological processes through the canonical pathway that involves ligands, RBPJ, proteases, and coactivators. However, recent studies in vertebrates and invertebrates reveal that Notch can also exert its effect independent of RBPJ, in a noncanonical fashion.
Jyothi Vijayaraghavan +1 more
openaire +1 more source
Discovered nearly a century ago, today, Notch is known to mediate several biological processes through the canonical pathway that involves ligands, RBPJ, proteases, and coactivators. However, recent studies in vertebrates and invertebrates reveal that Notch can also exert its effect independent of RBPJ, in a noncanonical fashion.
Jyothi Vijayaraghavan +1 more
openaire +1 more source
Notch Signaling in Solid Tumors
2010In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer. The finding that activating Notch mutations are frequently found in patients suffering from acute lymphoblastic leukemia is one of the best
Ute, Koch, Freddy, Radtke
openaire +2 more sources
Science Signaling, 2010
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling.
openaire +1 more source
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling.
openaire +1 more source
Biodiversity and Noncanonical Notch Signaling
2010Early genetics in flies revealed that Notch is a complex pleiotropic locus. We now know that Notch is a receptor that plays prominent roles during development and functions locally in many tissues to instruct cell fate decisions. Drosophila has been an excellent model to identify genetically the elements that contribute to the canonical Notch signaling
openaire +3 more sources
Notch signaling in lymphocyte development
Seminars in Immunology, 2002Cytokine and antigen receptor signals play well-characterized roles in promoting the survival and maturation of T and B lymphocyte progenitors through sequential developmental stages. Emerging studies suggest equally important roles for more ancient signaling pathways that evolved prior to the adaptive immune system in jawed vertebrates. In particular,
openaire +2 more sources
Notch Signaling and Breast Cancer
2012It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer.
openaire +2 more sources