Results 331 to 340 of about 133,611 (360)

Deciphering Notch signaling notch by notch

Cell Signaling, 2023
Lidia Borkiewicz, Adolfo Rivero-Müller
openaire   +1 more source

Glycosylation regulates Notch signalling

Nature Reviews Molecular Cell Biology, 2003
Intracellular post-translational modifications such as phosphorylation and ubiquitylation have been well studied for their roles in regulating diverse signalling pathways, but we are only just beginning to understand how differential glycosylation is used to regulate intercellular signalling.
Nicola, Haines, Kenneth D, Irvine
openaire   +2 more sources

Notch Signaling in Leukemias and Lymphomas

Current Molecular Medicine, 2008
Aberrant Notch activation is linked to cancer since 1991 when mammalian Notch1 was first identified as part of the translocation t(7;9) in a subset of human T-cell acute lymphoblastic leukemias (T-ALL). Since then oncogenic Notch signaling has been found in many solid and hematopoietic neoplasms.
Franziska, Jundt, Rolf, Schwarzer, Bernd, Dörken   +2 more
openaire   +2 more sources

Biodiversity and Noncanonical Notch Signaling

2010
Early genetics in flies revealed that Notch is a complex pleiotropic locus. We now know that Notch is a receptor that plays prominent roles during development and functions locally in many tissues to instruct cell fate decisions. Drosophila has been an excellent model to identify genetically the elements that contribute to the canonical Notch signaling
openaire   +3 more sources

Notch signaling in pediatric malignancies

Current Oncology Reports, 2008
Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected.
openaire   +2 more sources

Notch signaling in lymphocyte development

Seminars in Immunology, 2002
Cytokine and antigen receptor signals play well-characterized roles in promoting the survival and maturation of T and B lymphocyte progenitors through sequential developmental stages. Emerging studies suggest equally important roles for more ancient signaling pathways that evolved prior to the adaptive immune system in jawed vertebrates. In particular,
openaire   +2 more sources

Notch Signaling and Breast Cancer

2012
It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer.
openaire   +2 more sources

Role of Notch signaling in neurovascular aging and Alzheimer’s disease

Seminars in Cell and Developmental Biology, 2021
Arunima Kapoor, Daniel A Nation
exaly  

Notch Signaling

Journal of Neurosurgery, 2007
Sandra Hess, Michael Pfreundschuh, Beate Gleissner   +2 more
openaire   +1 more source

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

Cell, 2018
Meghan Mooring, Adam D Ewing, Adam M Novak   +2 more
exaly