Results 81 to 90 of about 152,934 (201)
European Journal of Inflammation, 2023 Objectives: The Notch signaling pathway serves as the key regulator of the biological functions of macrophages and may affect the role of macrophages in the development of pigeon breeder’s lung (PBL).
Wenyi Wang +7 more
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Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas
Neoplasia: An International Journal for Oncology Research, 2008 The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways.
Gilson S. Baia +5 more
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Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen +20 more
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Current views on the role of Notch signaling and the pathogenesis of human leukemia [PDF]
, 2011 The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis.
Joanna Pancewicz, Christophe Nicot
core +2 more sources
Defining the Role of Notch Signaling in Vascular Smooth Muscle Cell Differentiation [PDF]
, 2014 accepted into the Wilbert C. Jordan Student Research Forum hosted by the Student National Medical Association at the 50th Annual Medical Education ConferenceComplications resulting from vascular disease such as atherosclerosis are a major health concern ...
Jackson, Kamari
core
Molecular Therapy: Nucleic Acids, 2019 Atherosclerosis (AS) is a chronic inflammatory disease characterized by accumulating deposition of lipids in the arterial intima. Notably, macrophages participate centrally in the pathogenesis of this deadly disease.
Cheng-Gen Zheng +8 more
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Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]
, 2012 The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J. +2 more
core +1 more source
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling [PDF]
Journal of Cell Biology, 2015 Notch family members are transmembrane receptors that mediate essential developmental programs. Upon ligand binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the nucleus to regulate gene transcription. In addition, Notch trafficking across the endolysosomal system is critical in its regulation. In this study
Li, H. +13 more
openaire +7 more sources
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep [PDF]
, 2018 Additional file 6: Decreased lag-2 function does not slow vulval development. The progeny of wild type and lag-2(q420) animals raised at 25.5 °C were selected at the L4 stage, prior to lethargus entry. Vulval eversion was scored after 3 h; the percentage
Bennett, Heather L +7 more
core +4 more sources
The Roles of Notch Signaling in Liver Development and Disease
Biomolecules, 2019 The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understanding
Joshua M. Adams, Hamed Jafar-Nejad
doaj +1 more source