Results 61 to 70 of about 155,910 (299)

Cis-activation in the Notch signaling pathway

eLife, 2018
The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling. Here, by analyzing Notch activation in single cells while controlling cell density and ligand expression ...
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz   +2 more
openaire   +4 more sources

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +1 more source

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Cellular Physiology and Biochemistry, 2015
Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived ...
Bao-quan Song, Ying Chi, Xue Li, Wen-jing Du, Zhi-Bo Han, Jian-jian Tian, Juan-juan Li, Fang Chen, He-he Wu, Li-xin Han, Shi-hong Lu, Yi-zhou Zheng, Zhong-chao Han   +12 more
doaj   +1 more source

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]

, 2008
The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K., Jayasena, Chathurani S., Ohyama, Takahiro, Segil, Neil   +3 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

Cell Regeneration, 2012
Background Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic ...
Yin Wenguang, Liu Dapeng, Liu Nian, Xu Liangliang, Li Song, Lin Shuo, Shu Xiaodong, Pei Duanqing   +7 more
doaj   +1 more source

Biological Significance of NOTCH Signaling Strength

Frontiers in Cell and Developmental Biology, 2021
The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
doaj   +1 more source

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets [PDF]

PeerJ, 2020
Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis ...
Dimitrios Vlachakis, Louis Papageorgiou, Ariadne Papadaki, Maria Georga, Sofia Kossida, Elias Eliopoulos   +5 more
doaj   +2 more sources

Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]

, 2017
Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana, BUFALIERI, FRANCESCA, CHECQUOLO, Saula, DI MARCOTULLIO, LUCIA, FELLI, MARIA PIA, LAUER, DIETER MATTHIAS, NARDOZZA, FRANCESCA, PALERMO, ROCCO, PELULLO, MARIA, QUARANTA, ROBERTA, SCREPANTI, Isabella, TALORA, Claudio, VACCA, Alessandra, ZEMA, SABRINA   +13 more
core   +1 more source