Results 61 to 70 of about 1,848,500 (153)

The Notch Signaling Pathway

, 2023
Notch signaling is a signal transduction mechanism central to probably all multicellular organisms. Functional Notch signaling is required for normal development and homeostasis of most organs in the mammalian body, and mutations in the pathway are ...
Francesca Del Gaudio, Urban Lendahl, Del, Gaudio F,, Eike-Benjamin Braune, Lendahl, U,, Braune, E-B   +5 more
core   +1 more source

Role of the Notch signaling pathway in regulating macrophage polarization in a rat model of fibrotic pigeon breeder’s lung

European Journal of Inflammation, 2023
Objectives: The Notch signaling pathway serves as the key regulator of the biological functions of macrophages and may affect the role of macrophages in the development of pigeon breeder’s lung (PBL).
Wenyi Wang, Yaoyuan Shen, Qiuping Leng, Wei Ding, Zhen Peng, Yuan Zhou, Xiaohong Yang, Chao Wu   +7 more
doaj   +1 more source

Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review. [PDF]

J Asthma Allergy
Jingya Wang,1,2,* Kang Yan,3,* Leilei Ma,1,4,* Xianglei Yan,1 Zihan Meng,1 Ji-an Li,1 Meng Wang,1 Chenguang Du,1 Yueyue Yu1 1College of Traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, People’s Republic of ...
Wang J, Yan K, Ma L, Yan X, Meng Z, Li JA, Wang M, Du C, Yu Y.   +8 more
europepmc   +2 more sources

Molecular genetic analysis of a "sine oculis" enhancer and the "leventina" gene as a model system to study human macular degeneration in "Drosophila" [PDF]

, 2004
The leventina gene as a model system to study human macular degeneration in Drosophila. Age-related macular degeneration (AMD) is one of the most frequent reasons for blindness of the elderly people and accounts for approximately 50% of registered ...
Pauli, Tobias Samuel
core   +1 more source

Selective targeting of NOTCH-1 for therapeutic purposes in xenograft models of T-acute lymphoblastic leukemia [PDF]

, 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an heterogeneous disease, characterized by several genetic alterations and polymorphic clinical features both in children and adults.
Agnusdei, Valentina
core  

Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas

Neoplasia: An International Journal for Oncology Research, 2008
The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways.
Gilson S. Baia, Stefano Stifani, Edna T. Kimura, Michael W. McDermott, Russell O. Pieper, Anita Lal   +5 more
doaj   +1 more source

Inflammatory macrophages interrupt osteocyte maturation and mineralization via regulating the Notch signaling pathway

, 2022
BACKGROUND: It is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage-osteocyte interaction, and how their crosstalk could affect bone ...
Xiao, L, Zhou, Yinghong, Xiao, Lan, Prasadam, Indira, Crawford, Ross, Xiao, Yin, Prasadam, I, Wang, Shengfang, Zhou, Y, Wang, S, Crawford, R, Xiao, Y   +11 more
core   +1 more source

The Roles of Notch Signaling in Liver Development and Disease

Biomolecules, 2019
The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understanding
Joshua M. Adams, Hamed Jafar-Nejad
doaj   +1 more source

miR-133b Downregulation Reduces Vulnerable Plaque Formation in Mice with AS through Inhibiting Macrophage Immune Responses

Molecular Therapy: Nucleic Acids, 2019
Atherosclerosis (AS) is a chronic inflammatory disease characterized by accumulating deposition of lipids in the arterial intima. Notably, macrophages participate centrally in the pathogenesis of this deadly disease.
Cheng-Gen Zheng, Bing-Yu Chen, Ren-Hua Sun, Xiao-Zhou Mou, Fang Han, Qian Li, Hai-Jun Huang, Jing-Quan Liu, Yue-Xing Tu   +8 more
doaj   +1 more source

Correlation between granulocyte colony-stimulating factor and the Notch signaling pathway in ischemic brain injury

, 2021
Introduction This study aimed to determine the relationship between granulocyte colony-stimulating factor (G-CSF) and the Notch signaling pathway in ischemic brain injury.
Ning Xie, Qin Huang, Wenyuan Xu, Jingting Han   +3 more
core   +1 more source