Results 51 to 60 of about 1,848,500 (153)
Current research of the Notch pathway in hepatocellular carcinoma
European Journal of Medical ResearchNotch signaling is a widely preserved communication pathway that supports essential cellular functions by allowing adjacent cells to interact. The Notch signaling pathway consists of Notch ligands (DSL proteins), Notch receptors, DNA-binding proteins ...
Leiya Fu +4 more
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Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions
Journal of Diabetes Research, 2013 The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidney is established. Recently, the dysregulation of Notch signaling molecules has been identified in acute and chronic renal injuries, fibrosis models, and ...
Li Liu +6 more
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A study of Notch signalling in developmental angiogenesis [PDF]
, 2009 Blood vessel patterning during angiogenesis is a guided process. Endothelial tip cells located at the end of vascular sprouts are important for vessel guidance.
Phng, L.-K., Phng, L-K
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Fungal CSL transcription factors [PDF]
, 2007 Background: The CSL (CBF1/RBP-J kappa/Suppressor of Hairless/LAG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development. They function as
Prevorovsky, M +5 more
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Post-Developmental Roles of Notch Signaling in the Nervous System
Biomolecules, 2020 Since its discovery in Drosophila, the Notch signaling pathway has been studied in numerous developmental contexts in diverse multicellular organisms. The role of Notch signaling in nervous system development has been extensively investigated by numerous
Jose L. Salazar +2 more
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NOTCH Signaling in Osteosarcoma
Current Issues in Molecular Biology, 2023 The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high.
Zhenhao Zhang, Wei Wu, Zengwu Shao
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Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]
, 2013 The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn +25 more
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BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer. [PDF]
, 2021 Background: Several mechanisms likely cooperate with the mitogen-activated protein (MAP)-kinase pathway to promote cancer progression in the thyroid.
Traversi, Florian +3 more
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The roles and activation of endocardial Notch signaling in heart regeneration
Cell Regeneration, 2021 As a highly conserved signaling pathway in metazoans, the Notch pathway plays important roles in embryonic development and tissue regeneration. Recently, cardiac injury and regeneration have become an increasingly popular topic for biomedical research ...
Huicong Li +3 more
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Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [PDF]
, 2014 During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene ...
Dale, J. Kim +7 more
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