Results 31 to 40 of about 155,910 (299)

Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.

PLoS ONE, 2014
The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of ...
Li Li, Fenglong Zhao, Juan Lu, Tingting Li, Hong Yang, Chunhui Wu, Yiyao Liu   +6 more
doaj   +1 more source

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
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The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain

Molecular Brain, 2012
Background The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult animals.
Sun Yan-Yan, Li Li, Liu Xiao-Hua, Gu Nan, Dong Hai-Long, Xiong Lize   +5 more
doaj   +1 more source

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states [PDF]

, 2014
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch ...
Elowitz, Michael B., Jafar-Nejad, Hamed, LeBon, Lauren, Lee, Tom V., Sprinzak, David   +4 more
core   +1 more source

Evolving Roles of Notch Signaling in Cortical Development

Frontiers in Neuroscience, 2022
Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian, Fang-Shin Nian, Pei-Shan Hou, Pei-Shan Hou   +3 more
doaj   +1 more source

Notch signaling in serous ovarian cancer [PDF]

, 2014
Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors.
Foster, Rosemary, Groeneweg, Jolijn W, Growdon, Whitfield B, Rueda, Bo R, Verheijen, René HM   +4 more
core   +1 more source

Notch signalling pathway in development of cholangiocarcinoma

World Journal of Gastrointestinal Oncology, 2020
Cholangiocarcinoma (CCA) comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct. The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions.
Rauff, Bisma, Malik, Arif, Bhatti, Yasir Ali, Chudhary, Shafiq Ahmad, Qadri, Ishtiaq, Rafiq, Shafquat   +5 more
openaire   +2 more sources

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells [PDF]

, 2004
Introduction Notch signaling has been implicated in the regulation of cell-fate decisions such as self-renewal of adult stem cells and differentiation of progenitor cells along a particular lineage. Moreover, depending on the cellular and
IL Weissman, T Reya, GH Smith, G Dontu, BA Reynolds, L Miele, S Artavanis-Tsakonas, H Qi, L Li, E Six, T Kadesch, G Smith, H Uyttendaele, JV Soriano, A Diévart, K Brennan, J Stingl, VM Weaver, T Shimazaki, SJ Morrison, JS Mumm, S Jarriault, PS Rudland, D Nofziger, BJ Nickoloff, K Tanigaki, T Gudjonsson, S Weijzen, SJ Morrison, IL Weissman, L Krebs, K Siziopikou, A Imantani, K Fitzgerald, A Rangarajan, P Zagouras, F Radtke, H Uyttendaele, M Al-Hajj, G Dontu   +39 more
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Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling [PDF]

, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
A Djiane, A Ghysen, A Krejci, A Krejci, A Rogulja-Ortmann, A Schmid, AC Nagel, AM Bailey, B Kahali, B Kramatschek, B Pfeuty, BA Edgar, BE Housden, BE Housden, C Bivik, C Delidakis, C Peterson, C Ulvklo, CA Meyer, Caroline Bivik, CQ Doe, CQ Doe, CQ Doe, D Karlsson, D Karolchik, D Pan, DA Lehman, DF Poulson, E Knust, E Wurmbach, EC Lai, EC Lai, EP Spana, Erika Gunnar, F Liu, Francois Schweisguth, H Schmidt, H Schrons, I Miguel-Aliaga, I Rebay, I Wech, J Bischof, J Culi, J Hirata, JA Knoblich, JB Skeath, JB Skeath, JF de Celis, JL Cooper, JQ Boone, K Hori, K White, Khalil Mazouni, KJ Venken, L Jones, L Li, M Baumgardt, M Baumgardt, M Kohwi, M Lecourtois, MJ Lundell, MJ Vogel, N Giagtzoglou, O Birkholz, P Ligoxygakis, Paul H. Taghert, R Kageyama, R Kannan, R Karcavich, R Kopan, R Kopan, R Kushwah, R Lehmann, R Urbach, RL Trott, Ryan B. MacDonald, S Chanet, S Higashijima, S Yamamoto, SL Lai, SP Choksi, Stefan Thor, T Novotny, T Tsuji, TH Liu, UC Karandikar, YN Jan, Z Wang, Z Wang   +88 more
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The Notch signaling pathway: Transcriptional regulation at Notch target genes [PDF]

Cellular and Molecular Life Sciences, 2009
The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade. It plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development.
Borggrefe, T., Oswald, F.
openaire   +3 more sources