Results 31 to 40 of about 93,970 (258)

Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. [PDF]

PLoS ONE, 2012
BACKGROUND:Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both ...
Gengqiang Xie, Hongtao Zhang, Guiping Du, Qinglei Huang, Xuehong Liang, Jun Ma, Renjie Jiao   +6 more
doaj   +1 more source

Role of notch signaling pathway in Muc5ac secretion induced by atmospheric PM2.5 in rats

Ecotoxicology and Environmental Safety, 2022
Background: The secretion of Muc5ac is closely related to the pathogenesis, treatment and prognosis of bronchial asthma. Atmospheric PM2.5 entered the airway can irritate and corrode the bronchial wall, affecting the expression and secretion of Muc5ac ...
Ying Liu, Liting Zhou, Hanlin Wu, Yitong Wang, Danzengluobu, Bo Zhang   +5 more
doaj   +1 more source

NOTCH, a new signaling pathway implicated in holoprosencephaly [PDF]

Human Molecular Genetics, 2010
Genetics of Holoprosencephaly (HPE), a congenital malformation of the developing human forebrain, is due to multiple genetic defects. Most genes that have been implicated in HPE belong to the sonic hedgehog signaling pathway. Here we describe a new candidate gene isolated from array comparative genomic hybridization redundant 6qter deletions, DELTA ...
Dupé, Valérie, Rochard, Lucie, Mercier, Sandra, Le Pétillon, Yann, Gicquel, Isabelle, Bendavid, Claude, Bourrouillou, Georges, Kini, Usha, Thauvin-Robinet, Christel, Bohan, Timothy, Odent, Sylvie, Dubourg, Christèle, David, Véronique   +12 more
openaire   +3 more sources

Notch Signaling and T-Helper Cells in EAE/MS

Clinical and Developmental Immunology, 2013
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Ribal Bassil, William Orent, Wassim Elyaman   +2 more
doaj   +1 more source

Association between Notch signaling pathway and cancer

Acta Medica Lituanica, 2013
Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation.
Nadežda Lachej, Janina Didžiapetrienė, Birutė Kazbarienė, Daiva Kanopienė, Violeta Jonušienė   +4 more
doaj   +1 more source

The role of Hedgehog and Notch signaling pathway in cancer

Molecular Biomedicine, 2022
AbstractNotch and Hedgehog signaling are involved in cancer biology and pathology, including the maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor microenvironment. Given the complexity of Notch signaling in tumors, its role as both a tumor promoter and suppressor, and the crosstalk between pathways, the goal of developing ...
Ruolan Xia, Maosen Xu, Jing Yang, Xuelei Ma   +3 more
openaire   +3 more sources

The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC).
Jonas Ungerbäck, Nils Elander, John Grünberg, Mikael Sigvardsson, Peter Söderkvist   +4 more
doaj   +1 more source

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Cellular Physiology and Biochemistry, 2015
Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived ...
Bao-quan Song, Ying Chi, Xue Li, Wen-jing Du, Zhi-Bo Han, Jian-jian Tian, Juan-juan Li, Fang Chen, He-he Wu, Li-xin Han, Shi-hong Lu, Yi-zhou Zheng, Zhong-chao Han   +12 more
doaj   +1 more source