Results 31 to 40 of about 1,848,500 (153)

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

Notch Signaling and T-Helper Cells in EAE/MS

Clinical and Developmental Immunology, 2013
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Ribal Bassil, William Orent, Wassim Elyaman   +2 more
doaj   +1 more source

Association between Notch signaling pathway and cancer

Acta Medica Lituanica, 2013
Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation.
Nadežda Lachej, Janina Didžiapetrienė, Birutė Kazbarienė, Daiva Kanopienė, Violeta Jonušienė   +4 more
doaj   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]

, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

core   +2 more sources

The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC).
Jonas Ungerbäck, Nils Elander, John Grünberg, Mikael Sigvardsson, Peter Söderkvist   +4 more
doaj   +1 more source

Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
core   +1 more source

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +1 more source

Regulation of the self-renewal vs. differentiation decision in the C.elegans germline [PDF]

, 2011
Adult stem cells are the basis of our reproductive potential, of tissue growth and maintenance, and of wound healing and regeneration. Ageing phenotypes such as hair loss or brittle bones in fact reflect the gradual decline of the proliferative ...
Kalchhauser, Irene
core   +1 more source

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Cellular Physiology and Biochemistry, 2015
Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived ...
Bao-quan Song, Ying Chi, Xue Li, Wen-jing Du, Zhi-Bo Han, Jian-jian Tian, Juan-juan Li, Fang Chen, He-he Wu, Li-xin Han, Shi-hong Lu, Yi-zhou Zheng, Zhong-chao Han   +12 more
doaj   +1 more source

Notch1 signaling in the hepatic microcirculation and chronic liver disease [PDF]

, 2013
The Notch signaling pathway is an evolutionary conserved pathway that plays essential roles during vascular development and in the regulation of normal and pathological angiogenesis in the adulthood.
Rothweiler, Sonja
core   +1 more source