Results 21 to 30 of about 1,848,500 (153)
Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]
, 2006 A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G +14 more
core +1 more source
Notch2 signaling in development and cancer [PDF]
, 2012 Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core +1 more source
Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]
, 2006 Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
core +2 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj +1 more source
Active Notch signaling is required for arm regeneration in a brittle star.
PLoS ONE, 2020 Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including ...
Vladimir Mashanov +7 more
doaj +1 more source
The role of NOTCH2 gene in human malignant glial brain tumours [PDF]
, 2008 Background: Glioblastoma multiforme (GBM), astrocytoma (A) and oligodendroglioma (OG) are the neoplasms of the glial lineage in the Central Nervous System (CNS).
Sivasankaran, Balasubramanian
core +1 more source
Kaohsiung Journal of Medical Sciences, 2019 Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj +1 more source
Role of notch signaling pathway in Muc5ac secretion induced by atmospheric PM2.5 in rats
Ecotoxicology and Environmental Safety, 2022 Background: The secretion of Muc5ac is closely related to the pathogenesis, treatment and prognosis of bronchial asthma. Atmospheric PM2.5 entered the airway can irritate and corrode the bronchial wall, affecting the expression and secretion of Muc5ac ...
Ying Liu +5 more
doaj +1 more source
Role of Notch signaling in the mammalian heart
Brazilian Journal of Medical and Biological Research, 2014 Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
doaj +1 more source
Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. [PDF]
PLoS ONE, 2012 BACKGROUND:Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both ...
Gengqiang Xie +6 more
doaj +1 more source