Results 21 to 30 of about 93,970 (258)
Evolving Roles of Notch Signaling in Cortical Development
Frontiers in Neuroscience, 2022 Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian +3 more
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The Notch signaling pathway: Transcriptional regulation at Notch target genes [PDF]
Cellular and Molecular Life Sciences, 2009 The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade. It plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development.
Borggrefe, T., Oswald, F.
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The Notch Regulator Numb Links the Notch and TCR Signaling Pathways [PDF]
The Journal of Immunology, 2005 Abstract Both the Notch and TCR signaling pathways play an important role in T cell development, but the links between these signaling pathways are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of Notch and also contains a phosphotyrosine binding domain, suggesting that Numb could provide a link ...
Ana C, Anderson +6 more
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Clinical and Experimental Obstetrics & Gynecology, 2023 Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
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The Notch signaling pathway as a mediator of tumor survival [PDF]
Carcinogenesis, 2013 The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene transcription.
Kathleen M, Capaccione, Sharon R, Pine
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Active Notch signaling is required for arm regeneration in a brittle star.
PLoS ONE, 2020 Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including ...
Vladimir Mashanov +7 more
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The Notch signaling pathway in the cnidarian Hydra
Developmental Biology, 2007 Many of the major pathways that govern early development in higher animals have been identified in cnidarians, including the Wnt, TGFbeta and tyrosine kinase signaling pathways. We show here that Notch signaling is also conserved in these early metazoans.
Käsbauer, Tina +7 more
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Kaohsiung Journal of Medical Sciences, 2019 Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
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The Notch signalling pathway in hair growth
Mechanisms of Development, 1998 The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role.
Powell, B. +3 more
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Role of Notch signaling in the mammalian heart
Brazilian Journal of Medical and Biological Research, 2014 Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
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