Results 41 to 50 of about 1,848,500 (153)

Biological Significance of NOTCH Signaling Strength

Frontiers in Cell and Developmental Biology, 2021
The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
doaj   +1 more source

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]

, 2010
Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Mazur Pawel K., Radtke, Freddy, Freddy Radtke, Roland M Schmid, Schmid, Roland M., Nakhai Hassan, Grüner, Barbara M., Pawel K Mazur, Schmid Roland M., Barbara M. Grüner, Bence Sipos, Nakhai, Hassan, Jens T Siveke, Strobl Lothar J., Siveke, J.T., Mazur, P.K., Radtke Freddy, Sipos, Bence, Radtke, F., Barbara M Grüner, Zimber-Strobl Ursula, Nakhai, H., Jens T. Siveke, Sipos, B., Grüner, B.M., Schmid, R.M., Strobl, Lothar J., Grüner Barbara M., Strobl, L.J., Lothar J Strobl, Lothar J. Strobl, Zimber-Strobl, Ursula, Hassan Nakhai, Pawel K. Mazur, Roland M. Schmid, Mazur, Pawel K., Ursula Zimber-Strobl, Sipos Bence, Siveke Jens T., Zimber-Strobl, U., Siveke, Jens T.   +40 more
core   +3 more sources

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask

Cell Communication and Signaling
Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
doaj   +1 more source

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

Cell Regeneration, 2012
Background Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic ...
Yin Wenguang, Liu Dapeng, Liu Nian, Xu Liangliang, Li Song, Lin Shuo, Shu Xiaodong, Pei Duanqing   +7 more
doaj   +1 more source

Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases

Frontiers in Immunology, 2021
The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos, Torleif T. Gjølberg, Torleif T. Gjølberg, Torleif T. Gjølberg, Stig Krüger, Guttorm Haraldsen, Jan Terje Andersen, Jan Terje Andersen, Eirik Sundlisæter   +8 more
doaj   +1 more source

Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling

, 2011
Genome-wide association studies (GWAS) have identified SNPs associated with breast cancer. However, they offer limited insights about the biological mechanisms by which SNPs confer risk.
Chindo Hicks, Lucio Miele, Antonio Pannuti   +2 more
core   +1 more source

Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells

The Scientific World Journal, 2013
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Weiwei Liu, Guorong Jin, Chongde Long, Xin Zhou, Yan Tang, Shan Huang, Xielan Kuang, Lizi Wu, Qingjiong Zhang, Huangxuan Shen   +9 more
doaj   +1 more source

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets [PDF]

PeerJ, 2020
Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis ...
Dimitrios Vlachakis, Louis Papageorgiou, Ariadne Papadaki, Maria Georga, Sofia Kossida, Elias Eliopoulos   +5 more
doaj   +2 more sources

Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]

, 2005
In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core   +1 more source

Notch signaling in cancers: mechanism and potential therapy

Frontiers in Cell and Developmental Biology
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive
Chen Chen, Yan Du, Rongzu Nie, Shuangshuang Wang, Hang Wang, Peifeng Li   +5 more
doaj   +1 more source