Results 41 to 50 of about 155,910 (299)
Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation
Neoplasia: An International Journal for Oncology Research, 2019 Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon +6 more
doaj +1 more source
The Notch Regulator Numb Links the Notch and TCR Signaling Pathways [PDF]
The Journal of Immunology, 2005 Abstract Both the Notch and TCR signaling pathways play an important role in T cell development, but the links between these signaling pathways are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of Notch and also contains a phosphotyrosine binding domain, suggesting that Numb could provide a link ...
Ana C, Anderson +6 more
openaire +2 more sources
The Notch signaling pathway as a mediator of tumor survival [PDF]
Carcinogenesis, 2013 The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene transcription.
Kathleen M, Capaccione, Sharon R, Pine
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Clinical and Experimental Obstetrics & Gynecology, 2023 Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj +1 more source
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
The Notch signaling pathway in the cnidarian Hydra
Developmental Biology, 2007 Many of the major pathways that govern early development in higher animals have been identified in cnidarians, including the Wnt, TGFbeta and tyrosine kinase signaling pathways. We show here that Notch signaling is also conserved in these early metazoans.
Käsbauer, Tina +7 more
openaire +2 more sources
Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. [PDF]
PLoS ONE, 2012 BACKGROUND:Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both ...
Gengqiang Xie +6 more
doaj +1 more source
The Notch signalling pathway in hair growth
Mechanisms of Development, 1998 The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role.
Powell, B. +3 more
openaire +3 more sources
Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen +20 more
core +5 more sources