Notch Signaling Pathway and Human Placenta
International Journal of Medical Sciences, 2012 Notch signaling was evolutionarily conserved and critical for cell-fate determination, differentiation and many other biological processes. Growing evidences suggested that Notch signaling pathway played an important role in the mammalian placental ...
Wei-Xiu Zhao, Jian-Hua Lin
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BMC Cancer, 2022 Background The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for ...
Fei Wang +7 more
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The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]
, 2011 Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
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The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain
Molecular Brain, 2012 Background The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult animals.
Sun Yan-Yan +5 more
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Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]
, 2009 Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Naylor, Richard +7 more
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Evolving Roles of Notch Signaling in Cortical Development
Frontiers in Neuroscience, 2022 Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian +3 more
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The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]
, 2013 Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
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Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation
Neoplasia: An International Journal for Oncology Research, 2019 Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon +6 more
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Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. [PDF]
, 2015 The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic ...
Mark eEddison +9 more
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The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]
, 2004 The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
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