Results 11 to 20 of about 93,970 (258)
Notch Signaling Pathway and Human Placenta [PDF]
International Journal of Medical Sciences, 2012 Notch signaling was evolutionarily conserved and critical for cell-fate determination, differentiation and many other biological processes. Growing evidences suggested that Notch signaling pathway played an important role in the mammalian placental ...
Wei-Xiu Zhao, Jian-Hua Lin
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An Orthologics Study of the Notch Signaling Pathway. [PDF]
Genes (Basel)The Notch signaling pathway plays a major role in embryological development and in the ongoing life processes of many animals. Its role is to provide cell-to-cell communication in which a Sender cell, bearing membrane-embedded ligands, instructs a Receiver cell, bearing membrane-embedded receptors, to adopt one of two available fates.
Stein WD.
europepmc +3 more sources
Notch Signaling Pathway in Pancreatobiliary Tumors [PDF]
Medicina, 2021 Background and Objectives: The Notch signaling pathway plays an important role both in the development of the ductal systems of the pancreas and the bile ducts as well as in cancer development and progression. The aim of this study was to examine the expression of central proteins of the Notch signaling pathway in pancreatobiliary tumors and its ...
Francesca Borlak +8 more
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Ubiquitinations in the Notch Signaling Pathway [PDF]
International Journal of Molecular Sciences, 2013 The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules.
Moretti, Julien, Brou, Christel
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Mechanical regulation of the Notch signaling pathway
Current Opinion in Cell Biology, 2023 The mechanical regulation of Notch signaling is an emerging area of interest in cell biology. Notch is essential in many physiological processes in which mechanical stress plays an important role. This review provides an overview of the mechanoregulation of Notch signaling in multiple steps of the pathway. First, we discuss the current knowledge on the
Suarez Rodriguez, Freddy +2 more
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Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.
PLoS ONE, 2014 The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of ...
Li Li +6 more
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BMC Cancer, 2022 Background The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for ...
Fei Wang +7 more
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The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain
Molecular Brain, 2012 Background The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult animals.
Sun Yan-Yan +5 more
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Notch signalling pathway in development of cholangiocarcinoma
World Journal of Gastrointestinal Oncology, 2020 Cholangiocarcinoma (CCA) comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct. The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions.
Rauff, Bisma +5 more
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Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation
Neoplasia: An International Journal for Oncology Research, 2019 Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon +6 more
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