Results 11 to 20 of about 155,910 (299)
Notch Signaling and T-Helper Cells in EAE/MS [PDF]
Clinical and Developmental Immunology, 2013 The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Ribal Bassil +2 more
doaj +4 more sources
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
doaj +3 more sources
Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration [PDF]
Frontiers in Bioengineering and BiotechnologyThis review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration.
Yaping Liu +29 more
doaj +2 more sources
The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress [PDF]
Frontiers in ImmunologyThis article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological ...
Haokun Zhang +31 more
doaj +2 more sources
Notch Signaling Pathway and Human Placenta [PDF]
International Journal of Medical Sciences, 2012 Notch signaling was evolutionarily conserved and critical for cell-fate determination, differentiation and many other biological processes. Growing evidences suggested that Notch signaling pathway played an important role in the mammalian placental ...
Wei-Xiu Zhao, Jian-Hua Lin
doaj +3 more sources
Kaohsiung Journal of Medical Sciences, 2019 Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj +2 more sources
Role of the Notch signaling pathway in porcine oocyte maturation [PDF]
Cell Communication and SignalingBackground Although the Notch signaling pathway is known to play an important role in ovarian follicle development in mammals, whether it is involved in oocyte maturation remains unclear. Therefore, this study was performed to elucidate the existence and
Pil-Soo Jeong +7 more
doaj +2 more sources
Research Advances in Myocardial Infarction Repair and Cardiac Regenerative Medicine via the Notch Signaling Pathway [PDF]
Reviews in Cardiovascular MedicineAcute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary artery and severely affects public health.
Songyan Cai, Qingyuan Dai
doaj +2 more sources
An Orthologics Study of the Notch Signaling Pathway. [PDF]
Genes (Basel)The Notch signaling pathway plays a major role in embryological development and in the ongoing life processes of many animals. Its role is to provide cell-to-cell communication in which a Sender cell, bearing membrane-embedded ligands, instructs a Receiver cell, bearing membrane-embedded receptors, to adopt one of two available fates.
Stein WD.
europepmc +3 more sources
Notch Signaling Pathway in Pancreatobiliary Tumors [PDF]
Medicina, 2021 Background and Objectives: The Notch signaling pathway plays an important role both in the development of the ductal systems of the pancreas and the bile ducts as well as in cancer development and progression. The aim of this study was to examine the expression of central proteins of the Notch signaling pathway in pancreatobiliary tumors and its ...
Francesca Borlak +8 more
openaire +3 more sources