Results 81 to 90 of about 3,643,068 (293)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A leishmaniose no município de Porto Ferreira

Revista Brasileira de Enfermagem, 1996
O Município de Porto Ferreira-SP., por suas características geográficas, hidrográficas, topológicas e climáticas, associadas ao tipo de vegetação existente, favorece a procriação da espécie de flebotomíneos e conseqüentemente um aumento na incidência da ...
Edeltraut Nothing Zóia, Azumir E. Palombo, Elisete Silva Pedrazzani   +2 more
doaj   +1 more source

Locality from Quantum Gravity: All or Nothing

, 2017
In a full theory of quantum gravity, local physics is expected to be approximate rather than innate. It is therefore important to understand how approximate locality emerges in the semiclassical limit.
Engelhardt, Netta, Fischetti, Sebastian
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Nothing from Nothing

Neste artigo, discutem-se a teoria e a inspiração subjacentes à produção, realização e montagem de numa adaptação cinematográfica do Rei Lear de Shakespeare intitulada Nothing From Nothing (2024/2025). O objetivo é realçar o valor estético do nada, expondo a capacidade e o poder milagroso do nada para se criar a si próprio a partir de si próprio e para
openaire   +3 more sources

Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice

International Journal of COPD
Koichi Nishimura,1,2 Masaaki Kusunose,3 Ayumi Shibayama,4 Kazuhito Nakayasu5 1National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; 2Clinic Nishimura, Ayabe, Kyoto, Japan; 3Department of Respiratory Medicine, National Center for Geriatrics ...
Nishimura K, Kusunose M, Shibayama A, Nakayasu K   +3 more
doaj  

Archival Nothing

Current Musicology, 2018
As opposed to other realms of art, like literature or painting, a plethora of “great women singers” has existed in the Caribbean and Latin America since the recording industry began. These were marquee artists with legions of adoring fans.
Licia Fiol-Matta
doaj   +1 more source

New instabilities of de Sitter spacetimes

, 2010
We construct an instanton describing the pair production of non-Kaluza Klein bubbles of nothing in higher odd dimensional de Sitter spaces. In addition to showing that higher dimensional de Sitter spaces have a nonzero probability to become topologically
Keith Copsey, R. Garattini, Robert Mann
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source