Results 81 to 90 of about 4,292 (162)
The role of the notochord in amniote vertebral column segmentation [PDF]
, 2018 The vertebral column is segmented, comprising an alternating series of vertebrae and intervertebral discs along the head-tail axis. The vertebrae and outer portion (annulus fibrosus) of the disc are derived from the sclerotome part of the somites ...
Ward, L, Pang, ASW, Evans, SE, Stern, CD
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PLoS Biology, 2013 The appearance of the notochord represented a milestone in Deuterostome evolution. The notochord is necessary for the development of the chordate body plan and for the formation of the vertebral column and numerous organs.
Lavanya Katikala +9 more
doaj +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda +14 more
wiley +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche +9 more
wiley +1 more source
Biology Open, 2014 The node and notochord (and their equivalents in other species) are essential signaling centers, positioned along the plane of bilateral symmetry in developing vertebrate embryos. However, genes and mechanisms regulating morphogenesis of these structures
Maria Pulina, Dong Liang, Sophie Astrof
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My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley +1 more source
Mechanisms of Copper-Dependent Notochord Formation in Zebrafish [PDF]
, 2010 The interplay of genes and nutrition during early development profoundly impacts fetal outcome. Copper is an essential nutrient required for the redox activity of many enzymes, and recent work in our laboratory has elucidated the phenotype of copper ...
Gansner, John
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Notochord Morphogenesis: A Prickly Subject for Ascidians [PDF]
, 2005 Orchestrated cell movements marshalled by proper cell polarity in the developing body axes are fundamental to the elongation of the notochord during chordate embryogenesis.
Tada, Masazumi
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Matrix metalloproteinase Nas15 regulates the lumen formation and expansion in Ciona notochord
Frontiers in Ecology and EvolutionLumen formation, as a key process of biological tube construction, is essential in various physiological processes such as nutrient and waste transporting, gas exchanging, and structural supporting.
Jianqing Bi +6 more
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Sacrococcygeal chordoma in a 9-year-old boy Cordoma sacrococígeo em um menino de 9 anos de idade
Arquivos de Neuro-Psiquiatria, 1995 A case of sacrococcygeal chordoma in a 9-year-old boy is presented. The symptoms at presentation were pain in both legs and sacrococcygeal region for the last two years that increased in the last four weeks irradiating mainly to the left leg.
Lúcia de Noronha +4 more
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