Results 61 to 70 of about 9,104 (252)

Exploration of the Use of New Psychoactive Substances by Individuals in Treatment for Substance Misuse in the UK

Brain Sciences, 2018
Substance misuse services need to meet the growing demand and needs of individuals using new psychoactive substances (NPS). A review of the literature identified a paucity of research regarding NPS use by these individuals and UK guidelines outline the ...
Rosalind Gittins, Amira Guirguis, Fabrizio Schifano, Ian Maidment   +3 more
doaj   +1 more source

A Network Analysis of Alexithymia, Interoception, Empathy, Self‐Awareness and Psychopathological Symptoms in Young People With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with altered interoception, empathy, self‐awareness, and alexithymia. However, limited research has been conducted to investigate the interrelationships of these constructs with psychopathological symptoms.
Antonio Kei‐Fung Shek, Simon S. Y. Lui, Eric C. L. Lai, Raisie W. K. Wong, Jason L. F. Chan, Lok‐Yin Choi, Kimi H. Y. Lam, Eugenia Y. C. Lok, Siu‐Man Lam, Wang Yi, Raymond C. K. Chan   +10 more
wiley   +1 more source

Focus on Cognitive Enhancement: A Narrative Overview of Nootropics and “Smart Drug” Use and Misuse

Biology
Whilst “nootropics” are meant to treat a range of medical disorder-related cognitive impairments, the typically healthy “smart drugs” user ingests a range of drugs/molecules to achieve improved mental performance.
Fabrizio Schifano, Stefania Bonaccorso, Davide Arillotta, John Martin Corkery, Giuseppe Floresta, Gabriele Duccio Papanti Pelletier, Amira Guirguis   +6 more
doaj   +1 more source

Neurochemical profiles of some novel psychoactive substances

European Journal of Pharmacology, 2013
Fourteen substances from the class of drugs sometimes known as “legal highs” were screened against a battery of human receptors in binding assays, and their potencies as inhibitors of monoamine uptake determined in functional in vitro assays. Thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations ...
Iversen, Les, Gibbons, Simon, Treble, Ric, Setola, Vincent, Huang, Xi Ping, Roth, Bryan L.   +5 more
openaire   +4 more sources

Exposure, Extinction, and Cognitive Appraisals in Autistic Adults With Social Anxiety: Evidence From a Structured Speech Exposure Task

Autism Research, EarlyView.
ABSTRACT Social anxiety (SA) is highly prevalent among autistic adults, yet little is known about how autistic people respond to common therapeutic strategies, such as exposure tasks. This study examined responses to a structured speech exposure task embedded within an 8‐week modified cognitive–behavioral therapy (M‐CBT) program.
Bruna B. Roisenberg, Kelsie A. Boulton, Emma E. Thomas, Dorothy Yu, Adam J. Guastella   +4 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Linking Brain Morphometry to Psychometric Measures and Energy‐Metabolic Biomarkers in Adults With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both
Eleonora Esposto, Kathrin Nickel, Dominique Endres, Kimon Runge, Katharina Domschke, Thomas Lange, Marco Reisert, Anke Schumann, Cinzia Niolu, Ludger Tebartz van Elst, Simon Maier   +10 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Novel Psychoactive Spectra: NMR of (mostly) Novel Psychoactive Substances [PDF]

, 2017
1H NMR spectra of classical and novel psychoactive substances (NPS) are reported, including phenylethanamines (2-phenylethan-1-amines), phenylpropanamines (1-phenylpropan-2-amines), N-benzyl-phenylalkanamines, β-keto-phenylalkanamines (2-amino-1-phenylethan-1-ones and 2-amino-1-phenylpropan-1-ones), thiophenylpropanamines (1-(thiophen-2-yl)propan ...
openaire   +1 more source

Impact of secured prescription implementation on ambulatory pregabalin use in France: A regional assessment in the French Nouvelle‐Aquitaine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The French authorities mandated the use of secure prescriptions for pregabalin on May 2021. This study aimed to evaluate the impact of this measure on pregabalin use and misuse in Nouvelle‐Aquitaine, a southwestern French region with around six million inhabitants.
Maika Munech‐Herran, Véronique Moysan, Bruno Lescarret, Clément Mathieu, Antoine Pariente, Nicolas Rousselot   +5 more
wiley   +1 more source