Results 141 to 150 of about 974,149 (336)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Single view generalizable 3D reconstruction based on 3D Gaussian splatting

Scientific Reports
3D Gaussian Splatting (3DGS) has become a significant research focus in recent years, particularly for 3D reconstruction and novel view synthesis under non-ideal conditions.
Kun Fang, Qinghui Zhang, Chenxia Wan, Pengtao Lv, Cheng Yuan   +4 more
doaj   +1 more source

Dynamic Street-Scene Reconstruction with Semantic Priors and Temporal Constraints

Applied Sciences
Dynamic street-scene reconstruction from sparse viewpoints over long temporal spans is challenged by temporal instability, ghosting near occlusions, and background drift.
Qingwu Duan, Kaichen Ren, Mingsheng Huang, Jie Liu, Siyu Li, Sili Gao   +5 more
doaj   +1 more source

ContraNeRF: Generalizable Neural Radiance Fields for Synthetic-to-real Novel View Synthesis via Contrastive Learning [PDF]

, 2023
Hao Yang, Lanqing Hong, Aoxue Li, Tianyang Hu, Zhenguo Li, Gim Hee Lee, Liwei Wang   +6 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

EG-HumanNeRF: Efficient generalizable human NeRF utilizing human prior for sparse view

Computational Visual Media
Generalizable neural radiance fields (NeRFs) enable neural-based digital human rendering without per-scene retraining. When combined with human prior knowledge, high-quality human rendering can be achieved even with sparse input views.
Zhaorong Wang, Yoshihiro Kanamori, Yuki Endo   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

DiffLiGS: Diffusion-Guided LiDAR-Enhanced 3D Gaussian Splatting

ISPRS International Journal of Geo-Information
Multi-view 3D reconstruction is essential for smart city, supporting applications such as smart city planning and autonomous navigation. While traditional reconstruction pipelines and recent neural implicit methods, such as NeRF, achieve high visual ...
Shucheng Gong, Hong Xie, Jiang Song, Longze Zhu, Hongping Zhang   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Shadow-Aware Point-Based Neural Radiance Fields for High-Resolution Remote Sensing Novel View Synthesis

Remote Sensing
Novel view synthesis using neural radiance fields (NeRFs) for remote sensing images is important for various applications. Traditional methods often use implicit representations for modeling, which have slow rendering speeds and cannot directly obtain ...
Li Li, Yongsheng Zhang, Ziquan Wang, Zhenchao Zhang, Zhipeng Jiang, Ying Yu, Lei Li, Lei Zhang   +7 more
doaj   +1 more source