Results 151 to 160 of about 974,149 (336)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

View-Adaptive Gaussian Splatting With Dynamic Spherical Harmonics Modulation for Multi-Scale Urban Scene Rendering

IEEE Access
Despite recent advances in large-scale novel view synthesis centered around CityGaussian, performance degradation still occurs under extreme view-scale changes such as transitions between aerial and ground-level viewpoints.
Jiye Kim, Chanheum Yeon, Haeweon Jung, Eungyeom Yang, Jinho Lee   +4 more
doaj   +1 more source

Generalizable Novel-View Synthesis Using a Stereo Camera

2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)
Accepted to CVPR 2024. Project page URL: https://jinwonjoon.github.io/stereonerf/
Haechan Lee, Wonjoon Jin, Seung-Hwan Baek, Sunghyun Cho   +3 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

AnchorGS: Anchoring Gaussian Splatting to Planar Priors for Robust 3D Reconstruction

IEEE Access
Gaussian Splatting (GS) has emerged as an efficient and compelling method for novel view synthesis, offering real-time rendering and impressive visual fidelity.
Simon Tibensky, Gregor Rozinaj, Ivan Minarik, Marek Vanco, Jaroslav Venjarski   +4 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Novel UAV-based 3D reconstruction using dense LiDAR point cloud and imagery: A geometry-aware 3D gaussian splatting approach

International Journal of Applied Earth Observations and Geoinformation
The emergence of 3D Gaussian Splatting (3DGS) has recently marked a transformative shift in the realms of 3D representation, efficient rendering, and novel view synthesis.
Kai Qin, Jing Li, Sisi Zlatanova, Haitao Wu, Yin Gao, Yuchen Li, Sizhe Shen, Xiangjun Qu, Zhiyuan Yang, Zhenxin Zhang, Banghui Yang, Shaoyi Wang   +11 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source