Results 151 to 160 of about 882,347 (341)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Single view generalizable 3D reconstruction based on 3D Gaussian splatting
Scientific Reports3D Gaussian Splatting (3DGS) has become a significant research focus in recent years, particularly for 3D reconstruction and novel view synthesis under non-ideal conditions.
Kun Fang +4 more
doaj +1 more source
Few-Shot Remote Sensing Novel View Synthesis with Geometry Constraint NeRF
Guidance, Navigation and ControlNovel View Synthesis (NVS) is an important task for 3D interpretation in remote sensing scenes, which also benefits vicinagearth security by enhancing situational awareness capabilities.
Jiaming Kang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dynamic Street-Scene Reconstruction with Semantic Priors and Temporal Constraints
Applied SciencesDynamic street-scene reconstruction from sparse viewpoints over long temporal spans is challenged by temporal instability, ghosting near occlusions, and background drift.
Qingwu Duan +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Advanced Intelligent Systems3D Gaussian Splatting (3DGS) has emerged as a powerful framework for scene reconstruction and novel view synthesis for normal‐light and illumination‐consistent scenes.
Chengyun Yang +3 more
doaj +1 more source
DiffLiGS: Diffusion-Guided LiDAR-Enhanced 3D Gaussian Splatting
ISPRS International Journal of Geo-InformationMulti-view 3D reconstruction is essential for smart city, supporting applications such as smart city planning and autonomous navigation. While traditional reconstruction pipelines and recent neural implicit methods, such as NeRF, achieve high visual ...
Shucheng Gong +4 more
doaj +1 more source
A Solution for Scale Ambiguity in Generative Novel View Synthesis [PDF]
Generative Novel View Synthesis (GNVS) involves generating plausible unseen views of a scene given an initial view and the relative camera motion between the input and target views using generative models.
Forghani, Fereshteh
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source