Results 121 to 130 of about 13,156 (213)

The metabolism of APP protein in lysosomal storage disorders [PDF]

, 2009
Nedavna istraživanja su pokazala da povišena razina kolesterola može mijenjati cijepanje prekursora proteina amiloid-beta (APP) i utjecati na nakupljanje peptida amiloid-beta (Aβ), glavne patološke značajke Alzheimerove bolesti (AB).
Posavec, Melanija
core   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Sterol-binding proteins in late endosomes : Regulation of endosome motility and lipid metabolism [PDF]

, 2011
Despite its bad reputation in the mass media, cholesterol is an indispensable constituent of cellular membranes and vertebrate life. It is, however, also potentially lethal as it may accumulate in the arterial intima causing atherosclerosis or elsewhere ...
Uronen, Riikka-Liisa
core  

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

mSphere, 2016
Filoviruses are the causative agents of an increasing number of disease outbreaks in human populations, including the current unprecedented Ebola virus disease (EVD) outbreak in western Africa.
Esther Ndungo, Andrew S. Herbert, Matthijs Raaben, Gregor Obernosterer, Rohan Biswas, Emily Happy Miller, Ariel S. Wirchnianski, Jan E. Carette, Thijn R. Brummelkamp, Sean P. Whelan, John M. Dye, Kartik Chandran   +11 more
doaj   +1 more source

ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis

Journal of Lipid Research
Niemann-Pick type C1 (NPC1) disease is a rare neurodegenerative cholesterol and sphingolipid storage disorder primarily due to mutations in the cholesterol-trafficking protein NPC1.
Ryan D.R. Brown, Usha Mahawar, Binks W. Wattenberg, Sarah Spiegel   +3 more
doaj   +1 more source

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK [PDF]

, 2017
Austin, Christopher P., Dai, Sheng, Dulcey, Andres E., Hu, Xin, Marugan, Juan, Ory, Daniel S., Porter, Forbes D., Wassif, Christopher A., Zheng, Wei   +8 more
core   +2 more sources

NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression

Nature Communications
Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang   +7 more
doaj   +1 more source

Lipid transporters and binding proteins; MsbA and NPC1

The FASEB Journal, 2010
Understanding the molecular mechanism of proteins that translocate or transfer lipids presents a special challenge. The bacterial ABC protein, MsbA, is a homodimeric “half‐transporter” of known structure, which is thought to act as an outwardly‐directed ATP‐driven flippase for lipid A and possibly some ...
openaire   +1 more source

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

FEBS Open Bio
Hepatocellular carcinoma remains a significant threat to human health. Recent studies have found that the intake of cellular cholesterol contributes to the development and progression of hepatocellular carcinoma, although the exact mechanisms remain ...
Songhai Yang, Jiangming Chen, Kun Xie, Fubao Liu   +3 more
doaj   +1 more source

Intracellular cholesterol transport proteins: roles in health and disease [PDF]

, 2016
Graham, Annette, Soffientini, Ugo
core   +1 more source