Results 101 to 110 of about 13,156 (213)
, 2019 The performance of lithium and sodium ion batteries relies notably on the accessibility to carbon electrodes of controllable porous structure and chemical composition.
Alkarmo, Walid +8 more
core +1 more source
Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C [PDF]
, 2016 Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by the occurrence of visceral and neurological symptoms. At present, the molecular mechanisms causing neurodegeneration in this disease are unknown.
Bembi, Bruno +9 more
core +3 more sources
British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy +16 more
wiley +1 more source
Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein [PDF]
, 2018 We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green ...
Annaert, Wim +6 more
core +1 more source
Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.ABSTRACT Three‐dimensional (3D) genome organization is dynamically restructured during early vertebrate development, yet how chromatin domains are established remains poorly understood. In particular, the contribution of individual cohesin regulators to this process during embryogenesis is unclear.
Shinra Ikeda +2 more
wiley +1 more source
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. [PDF]
, 2019 To understand the impact of epigenetics on human misfolding disease, we apply Gaussian-process regression (GPR) based machine learning (ML) (GPR-ML) through variation spatial profiling (VSP). VSP generates population-based matrices describing the spatial
Balch, William E +8 more
core +1 more source
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. [PDF]
, 2016 Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce.
Aho, Vilma +2 more
core +2 more sources
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi +11 more
wiley +1 more source
Niemann-Pick NPC1: Sterols to the Rescue and Beyond
Chemistry & Biology, 2013 In Niemann-Pick type C disease, the most prevalent I1061T mutation inhibits folding and trafficking of the NPC1 protein to the endosomes/lysosomes. In this issue of Chemistry & Biology, Ohgane and colleagues used pharmacological chaperones to repair the defect and identify a second sterol-binding site.
Loo, Tip W., Clarke, David M.
openaire +2 more sources
Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells [PDF]
, 2017 Wolbachia are intracellular maternally inherited bacteria that can spread through insect populations and block virus transmission by mosquitoes, providing an important approach to dengue control.
Ant, Thomas H. +9 more
core +3 more sources