Results 231 to 240 of about 7,302 (251)

An NPC1L1 gene promoter variant is associated with autosomal dominant hypercholesterolemia

Nutrition, Metabolism and Cardiovascular Diseases, 2010
A substantial number of subjects with autosomal dominant hypercholesterolemia (ADH) do not have LDL receptor (LDLR) or apolipoprotein B (APOB) mutations. Some ADH subjects appear to hyperabsorb sterols from the intestine, thus we hypothesized that they could have variants of the Niemann-Pick C1-Like 1 gene (NPC1L1).
B, Martín, M, Solanas-Barca, A-L, García-Otín, S, Pampín, M, Cofán, E, Ros, J-C, Rodríguez-Rey, M, Pocoví, F, Civeira   +8 more
openaire   +2 more sources

VARIATION IN HMGCR AND NPC1L1 AND INFLAMMATORY BIOMARKERS

Journal of the American College of Cardiology, 2022
Jiawen Li, Xiao-Fang Tang, Jingjing Xu, Ru Liu, Yulong Li, Lei Song, Jinqing Yuan, Xueyan Zhao   +7 more
openaire   +1 more source

640 NPC1L1 GENE POLYMORPHISMS AFFECTING CHOLESTEROL ABSORPTION

Atherosclerosis Supplements, 2011
T. Maeda, M. Numakura, Y. Mashimo, N. Yoshimura, J. Kusano, T. Ishikawa, K. Murata, M. Fujita, A. Honda, M. Kinoshita, Y. Matsuzaki, T. Teramoto   +11 more
openaire   +1 more source

NPC1L1 mutations lower CHD risk

Nature Reviews Cardiology, 2014
openaire   +1 more source

Synthesis of Cholesterol Transporter NPC1L1 Inhibitor

Synfacts, 2011
openaire   +1 more source

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

Nature Medicine, 2013
Zhen-Yan Fu, Ying-Yu Zhang, Yi-tong
exaly  

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

Cell Metabolism, 2008
Liang Ge, Wei Qi, Jian Cao
exaly  

The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake

Journal of Biological Chemistry, 2011
Liang Ge, Wei Qi, Bao-Liang Song
exaly  

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

Annual Review of Physiology, 2011
Lin Jia, Liqing Yu
exaly  

Hepatic NPC1L1 Overexpression Ameliorates Glucose Metabolism in Diabetic Mice Via Suppression of Gluconeogenesis

Metabolism: Clinical and Experimental, 2015
Makoto Kurano, Hiroaki Satoh
exaly