Results 51 to 60 of about 400,216 (332)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity
eLife, 2021 Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not glucose concentration, enhances the spiking activity of neurons of the ...
Anastassios Karagiannis +17 more
doaj +1 more source
Different Physiological and Biochemical Responses of Bamboo to the Addition of TiO2 NPs under Heavy Metal Toxicity [PDF]
, 2021 Abolghassem Emamverdian +5 more
openalex +1 more source
Salient selves in uncertain futures [PDF]
, 2020 We examined possible selves during three distinct periods of uncertainty. Cancer survivors (Study 1a) and survivors’ romantic partners (Study 1b) rated the salience of possible selves in which the cancer did (negative possible self; NPS) and did not ...
Dunlop, WL, Sweeny, K
core +1 more source
Transcript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice – Effects of peripheral axotomy or hindpaw inflammation [PDF]
, 2013 Using specific riboprobes, we characterized the expression of vesicular glutamate transporter (VGLUT)1–VGLUT3 transcripts in lumbar 4–5 (L4–5) dorsal root ganglions (DRGs) and the thoracolumbar to lumbosacral spinal cord in male BALB/c mice after a 1- or
Brumovsky, Pablo Rodolfo +8 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2017 In September, 10 advanced practice nurses from the Department of Surgery gathered for a lunchtime kick-off meeting to form a Nurse Practitioners (NPs) & Physician Assistants (PAs) Professionalism and Scholarship Working Group.
core +2 more sources
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Brain Sciences, 2020 New/novel psychoactive substances (NPS) are defined as new narcotic/psychotropic drugs which are not controlled by the United Nations’ 1961 Narcotic Drugs/1971 Psychotropic Substances conventions, but which may pose a public health threat [...]
Fabrizio Schifano
doaj +1 more source
EPR and Structural Characterization of Water-Soluble Mn2+-Doped Si Nanoparticles. [PDF]
, 2017 Water-soluble poly(allylamine) Mn2+-doped Si (SiMn) nanoparticles (NPs) were prepared and show promise for biologically related applications. The nanoparticles show both strong photoluminescence and good magnetic resonance contrast imaging.
Atkins, Tonya M +6 more
core +3 more sources