The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Journal of Internal Medicine, EarlyView.Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
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Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors [PDF]
, 1999 C. Li
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The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
Obesity Reviews, EarlyView.ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin +6 more
wiley +1 more source
Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception
Orthodontics &Craniofacial Research, EarlyView.ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
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Experimental Physiology, EarlyView.Abstract Topical application of l‐menthol, a pharmacological cold‐mimetic and agonist of the cold‐sensing receptor TRPM8 (transient receptor potential cation channel subfamily M member 8), has been shown to stimulate brown adipose tissue (BAT) thermogenesis and reduce weight gain in both obese and lean male mice, without affecting energy intake.
Annalaura Bellucci +8 more
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Influence of TASP‐V, a novel neuropeptide Y (NPY) Y2 agonist, on nasal and bronchial responses evoked by histamine in anaesthetized pigs and in humans [PDF]
, 1999 Didier‐David Malis +4 more
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Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression
Autophagy, 2016 Tae Seok Oh +4 more
semanticscholar +1 more source
Coexisting NPY and NE synergistically regulate renal tubular Na+, K+-ATPase activity
, 1994 Yoshiyuki Ohtomo +3 more
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Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, EarlyView.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source