Results 11 to 20 of about 33,925 (257)

Distinction of NPY receptors in vitro and in vivo. II. Differential effects of NPY and NPY-(18-36)

American Journal of Physiology-Heart and Circulatory Physiology, 1990
We have studied the hemodynamic effects of neuropeptide Y (NPY) and its COOH-terminal fragment NPY-(18–36) in conscious rats. Intra-arterial injection of NPY rapidly elevated systemic vascular resistance (SVR), which remained high for greater than 30 min. Cardiac output (CO) decreased, and it remained low for greater than 30 min.
Scott, N. A., Michel, M. C., Boublik, J. H., Rivier, J. E., Motomura, S., Crum, R. L., Landon, M., Brown, M. R.   +7 more
core   +5 more sources

NPY and Cardiac Diseases

Current Topics in Medicinal Chemistry, 2007
Hypertension-induced left ventricular hypertrophy (LVH), along with ischemic heart disease, result in LV remodeling as part of a continuum that often leads to congestive heart failure. The neurohormonal model has been used to underpin many treatment strategies, but optimal outcomes have not been achieved.
McDermott, Barbara, Bell, David
core   +5 more sources

Distinction of NPY receptors in vitro and in vivo. I. NPY-(18-36) discriminates NPY receptor subtypes in vitro

American Journal of Physiology-Endocrinology and Metabolism, 1990
We studied the possibility of multiple neuropeptide Y (NPY) receptor subtypes. NPY-stimulated Ca2+ mobilization in human erythroleukemia (HEL) cells was used to screen a number of NPY analogues. The potencies of three of these analogues [peptide YY (PYY), [D-Tyr-36]NPY, and NPY-(18-36)] were compared with that of NPY in the following model systems: Ca2+
Michel, M. C., Schlicker, E., Fink, K., Boublik, J. H., Göthert, M., Willette, R. N., Daly, R. N., Hieble, J. P., Rivier, J. E., Motulsky, H. J.   +9 more
openaire   +4 more sources

Neuropeptide Y (NPY) : A neurogenic mediator of angiogenesis

, 2004
NPY, previously known as a sympathetic vasoconstricting co-transmitter, recently has also emerged as an important vascular growth factor, stimulating proliferation of vascular smooth muscle and endothelial cells (ECs).
Michalkiewicz, Mieczyslaw, Lee, Edward W, Kuo, Lydia E, Kítlinska, Johanna B, Kalezic, Ivana,, Ljubisavlejvic, Milos,, Zukowska, Zofia   +6 more
core   +9 more sources

NPY in alcoholism and psychiatric disorders

, 2006
The NPY system may well be one of the most interesting target systems for development of treatments for alcohol dependence as well as mood disorders such as depression and anxiety syndromes. NPY is an endogenous anxiolytic compound, functions as an antidepressant, and is effective in modifying alcohol intake in high drinking states.
Annika, Thorsell, Rose-Marie, Karlsson, Markus, Heilig   +2 more
openaire   +3 more sources

Neuropeptide Y (NPY) and NPY Y1 receptor in periodontal health and disease

Archives of Oral Biology, 2009
Neuropeptide Y (NPY) coordinates inflammation and bone metabolism which are central to the pathogenesis of periodontitis. The present study was designed to determine whether NPY was quantifiable in human gingival crevicular fluid (GCF) and to test the null hypothesis that GCF levels of NPY were the same in periodontal health and disease.
Lundy, Fionnuala T., El Karim, Ikhlas A., Linden, Gerard J.   +2 more
openaire   +4 more sources

Neuropeptide Y-Graphene Oxide Complexes Inhibit Amygdala NPY-Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo. [PDF]

Adv Sci (Weinh)
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Pati E, Franceschi Biagioni A, Casani R, Arellano LM, Battisti T, Garcia-Ortega G, Lozano N, Bianco A, Kostarelos K, Ballerini L, Cellot G.   +10 more
europepmc   +2 more sources

The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice [PDF]

Journal of Integrative Neuroscience, 2022
Insulin is known to act in the central nervous system to regulate several physiological and behavioural outcomes, including energy balance, glucose homeostasis and cognitive functioning. However, the neuronal populations through which insulin enhances
Elisabeth K. Goodman, Caitlin S. Mitchell, Jonathan D. Teo, Joanne M. Gladding, Kirsten N. Abbott, Neda Rafiei, Lei Zhang, Herbert Herzog, Denovan P. Begg   +8 more
doaj   +1 more source

Interaction of central kisspeptin with melanocortin, GABAergic, corticotrophin, and NPY systems on food intake in chickens [PDF]

The Iranian Journal of Veterinary Science and Technology, 2022
Kisspeptin is a key component of reproduction that can directly affect food intake in mammals. There is evidence suggesting that melanocortin, GABA, corticotrophin, and neuropeptide Y (NPY), have a mediatory role in reward; however, how these substances ...
Ahmadreza Kord, Bita Vazir, Morteza Zendedel kheybari, Vahab Babapour, Ahmad Asghari   +4 more
doaj   +1 more source

<i>Hj</i>-aggregates of quinoline-fused boron-dipyrromethene nanoparticles for near-infrared dualmodal photodynamic and photothermal therapy. [PDF]

Smart Mol
A novel quinoline‐fused cyclic pyrrole is synthesized via lithium diisopropylamide‐catalyzed [3 + 2] cyclization, enabling the construction of a symmetrical boron‐dipyrromethene photosensitizer that forms Hj‐aggregates upon nanoparticle encapsulation.
Zhang B, Du C, Yang Y, Xu D, Jiang XD, Liu HX, Qin G.   +6 more
europepmc   +2 more sources