Results 41 to 50 of about 33,925 (257)

Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice

Annals of Clinical and Translational Neurology, 2023
Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), recent evidence supports a link ...
Rosemary M. Clark, Courtney M. Clark, Katherine E.A. Lewis, Marcus S. Dyer, Jyoti A. Chuckowree, Joshua A. Hoyle, Catherine A. Blizzard, Tracey C. Dickson   +7 more
doaj   +1 more source

Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells [PDF]

, 2013
Background Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver ...
Vander Borght, S, McKee, C, Vander Borght Sara, Mazzoccoli, G, Ching-I Lin, Gianluigi Mazzoccoli, Lin Ching-I, Selden, C, Maelle Morgan, Pazienza Valerio, Selden Clare, Junpei Soeda, Jude A Oben, Barbara Sigala, Manlio Vinciguerra, Oben, JA, Tania Roskams, Sara Vander Borght, Pazienza, V, Roskams, T, Clare Selden, Lin, CI, McKee Chad, Mazzoccoli Gianluigi, Vinciguerra, M, Morgan Maelle, Valerio Pazienza, Sigala Barbara, Vinciguerra Manlio, Soeda, J, Chad McKee, Soeda Junpei, Oben Jude A., Sigala, B, Roskams Tania, Morgan, M   +35 more
core   +2 more sources

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Transcriptional Regulation of Neuropeptide Y Gene by Leptin and Its Effect on Feeding

Journal of Pharmacological Sciences, 2005
Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus.
Hiroshi Higuchi, Ayumi Hasegawa, Tsuyoshi Yamaguchi   +2 more
doaj   +1 more source

Central Interaction Between L-Ornithine and Neuropeptide Y in the Regulation of Feeding Behavior of Neonatal Chicks

The Journal of Poultry Science, 2023
Ornithine has been identified as a potential satiety signal in the brains of neonatal chicks. We hypothesized that brain nutrient signals such as amino acids and appetite-related neuropeptides synergistically regulate food intake. To test this hypothesis,
Phuong V. Tran, Mohamed Z. Elhussiny, Yuriko Tsuru, Ying Wang, Guofeng Han, Vishwajit S. Chowdhury, Mitsuhiro Furuse   +6 more
doaj   +1 more source

Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis

Journal of Immunology Research, 2020
Background. Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood.
Melissa Ramirez-Villafaña, Ana M. Saldaña-Cruz, Javier A. Aceves-Aceves, Edsaul E. Perez-Guerrero, Nicté S. Fajardo-Robledo, Edy D. Rubio-Arellano, Cesar A. Nava-Valdivia, Maria O. Carrillo-Escalante, Sylvia E. Totsuka-Sutto, David Cardona-Müller, Betsabe Contreras-Haro, Mario Salazar-Paramo, Ernesto G. Cardona-Muñoz, M. Huerta, Jorge I. Gamez-Nava, Norma A. Rodriguez-Jimenez, Laura Gonzalez-Lopez   +16 more
doaj   +1 more source

NPY and Gene Therapy for Epilepsy: How, When,... and Y

Frontiers in Molecular Neuroscience, 2021
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell proliferation, cardiovascular and metabolic function, pain and neuronal excitability.
Stefano Cattaneo, Stefano Cattaneo, Gianluca Verlengia, Gianluca Verlengia, Pietro Marino, Pietro Marino, Michele Simonato, Michele Simonato, Michele Simonato, Barbara Bettegazzi, Barbara Bettegazzi   +10 more
doaj   +1 more source

Efferent and Afferent Connections of Neuropeptide Y Neurons in the Nucleus Accumbens of Mice

Frontiers in Neuroanatomy, 2021
Neuropeptide Y (NPY) is a neural peptide distributed widely in the brain and has various functions in each region. We previously reported that NPY neurons in the nucleus accumbens (NAc) are involved in the regulation of anxiety behavior.
Shunji Yamada, Nienke van Kooten, Takuma Mori, Katsutoshi Taguchi, Atsushi Tsujimura, Masaki Tanaka   +5 more
doaj   +1 more source

Neuropeptide Y Variation Is Associated With Altered Static and Dynamic Functional Connectivity of the Salience Network

Frontiers in Systems Neuroscience, 2021
Neuropeptide Y (NPY) is a neurotransmitter that has been implicated in the development of anxiety and mood disorders. Low levels of NPY have been associated with risk for these disorders, and high levels with resilience.
Katherine G. Warthen, Robert C. Welsh, Benjamin Sanford, Vincent Koppelmans, Margit Burmeister, Brian J. Mickey   +5 more
doaj   +1 more source

Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.

PLoS ONE, 2013
Neuropeptide Y (NPY) is induced in peripheral tissues such as adipose tissue with obesity. The mechanism and function of NPY induction in fat are unclear.
Kanakadurga Singer, David L Morris, David L Morris, Kelsie E Oatmen, Tianyi Wang, Jennifer DelProposto, Taleen Mergian, Kae Won Cho, Carey N Lumeng   +8 more
doaj   +1 more source

Quantification of Neuropeptide Y with Picomolar Sensitivity Enabled by Guided-Mode Resonance Biosensors

Sensors, 2019
Assessing levels of neuropeptide Y (NPY) in the human body has many medical uses. Accordingly, we report the quantitative detection of NPY biomarkers applying guided-mode resonance (GMR) biosensor methodology.
Mohammad G. Abdallah, Joseph A. Buchanan-Vega, Kyu J. Lee, Brett R. Wenner, Jeffery W. Allen, Monica S. Allen, Susanne Gimlin, Debra Wawro Weidanz, Robert Magnusson   +8 more
doaj   +1 more source