Results 61 to 70 of about 33,925 (257)

GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.

PLoS Biology, 2023
It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food ...
Youjin Oh, Eun-Seon Yoo, Sang Hyeon Ju, Eunha Kim, Seulgi Lee, Seyun Kim, Kevin Wickman, Jong-Woo Sohn   +7 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Differential regulation of Neuropeptide Y (NPY) in the amygdala and prefrontal cortex during recovery from chronic variable stress (CVS)

Frontiers in Behavioral Neuroscience, 2011
Accumulating evidence from clinical studies and pre-clinical animal models supports a role for neuropeptide Y (NPY) in adaptive emotional response following stress. The long-term impact of stress, particularly chronic stress, on availability and function
Jennifer Lynne McGuire, Jennifer Lynne McGuire, Lauren eLarke, Floyd eSallee, James eHerman, James eHerman, Renu eSah, Renu eSah   +7 more
doaj   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

AgRP1 modulates breeding season-dependent feeding behavior in female medaka

eLife
Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior.
Yurika Tagui, Shingo Takeda, Hiroyo Waida, Shoichi Kitahara, Tomoki Kimura, Shinji Kanda, Yoshitaka Oka, Yu Hayashi, Chie Umatani   +8 more
doaj   +1 more source

Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice. [PDF]

J Neuroendocrinol
Abstract Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological ...
Young LA, Hurtado ER, Jacobs KD, Lee ZMM, Nestor CC, McCosh RB.   +5 more
europepmc   +2 more sources

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

NPY-8 targets npyr-1⁺ neuroendocrine cells in the CNS.

, 2016
(A) Schematic of receptor-activation assay performed in CHO/mtAEQ/G16 cells. Candidate GPCRs were expressed transiently in a cell line that enables visualization of calcium mobilization upon receptor activation.
Liliane Schoofs (191818), Isabel Beets (844259), Ayana Jamal (2741842), Amir Saberi (240055), Phillip A. Newmark (228342)   +4 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Role of neuropeptide Y in development of valproate-induced eating behaviour disorder

Эпилепсия и пароксизмальные состояния
Background. Eating behaviour disorder (EBD) induced by valproic acid (VPA) is one of the components of the pathogenesis of a serious complication of therapy with VPA and its salts such as VPA-induced metabolic syndrome (MetS).
N. A. Shnayder, V. V. Grechkina, M. Ya. Kissin, D. V. Dmitrenko, R. F. Nasyrova   +4 more
doaj   +1 more source