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Spinal mechanisms of NPY analgesia
Peptides, 2007We review previously published data, and present some new data, indicating that spinal application of neuropeptide Y (NPY) reduces behavioral and neurophysiological signs of acute and chronic pain. In models of acute pain, early behavioral studies showed that spinal (intrathecal) administration of NPY and Y2 receptor agonists decrease thermal ...
Peter A. Smith +4 more
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NPY in alcoholism and psychiatric disorders
2006The NPY system may well be one of the most interesting target systems for development of treatments for alcohol dependence as well as mood disorders such as depression and anxiety syndromes. NPY is an endogenous anxiolytic compound, functions as an antidepressant, and is effective in modifying alcohol intake in high drinking states.
Markus Heilig +2 more
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Interactions between NPY and its receptor: assessment using anti-NPY antibodies
Regulatory Peptides, 1994The present data show that monoclonal antibodies (NPY02, NPY03, NPY04, NPY05) directed against 4 distinct epitopes on NPY may have different actions on NPY binding and NPY-induced cellular responses. NPY02 and NPY05 recognize the 11-24 and 32-36 amidated form of NPY, respectively.
Grouzmann, E. +5 more
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Is there really an NPY Y3 receptor?
Regulatory Peptides, 1998NPY is an abundant neuropeptide that is widely distributed throughout the central and peripheral nervous systems. Based on pharmacological and cloning data, there are believed to be six different types of NPY receptors. The Y3 receptor is the only one of the six that has not been cloned or well characterized.
Chong C. Lee, Richard J. Miller
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Regulatory Peptides, 1997
Neuropeptide Y (NPY) is widely distributed throughout the central and peripheral nervous system and exerts a wide range of physiological responses by activating specific receptors. In this study we have characterized the potency of the high affinity peptide dimer antagonist, GR231118, to displace radiolabeled NPY/PYY from different tissues and cell ...
Kerry J Koller +6 more
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Neuropeptide Y (NPY) is widely distributed throughout the central and peripheral nervous system and exerts a wide range of physiological responses by activating specific receptors. In this study we have characterized the potency of the high affinity peptide dimer antagonist, GR231118, to displace radiolabeled NPY/PYY from different tissues and cell ...
Kerry J Koller +6 more
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Effects of neuropeptide Y (NPY) and NPY agonists on lordosis in the female guinea pig
Endocrine, 1996We have previously shown that an NPY antagonist decreases lordosis behavior and that this decrease can be reversed with NPY administration. The present experiments examined whether intracerebroventricular (icv) administration of NPY would facilitate lordosis behavior and whether it would increase feeding behavior in the female guinea pig. Additionally,
Janice E. Thornton +3 more
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NPY and Hippocampal Neurogenesis
2005The chronic behavioural and cognitive effects of NPY may be partly mediated by Y1 receptor effects on stem cell proliferation and neurogenesis in the dentate gyrus of the adult hippocampus. Further investigation of this mechanism of NPY function is likely to be helpful is dissociating the acute and chronic effects of NPY on cognition and behaviour and ...
Helen E. Scharfman, William P. Gray
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995
Two catabolic states leading to loss of body weight were compared in the Djungarian hamster (Phodopus sungorus campbelli). Hypothalamic neuropeptide Y (NPY) and gene expression for NPY and corticotropin-releasing factor (CRF) were examined after withdrawal of food for 48 h or exposure to short photoperiod for 10 or 20 wk.
B Beck +5 more
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Two catabolic states leading to loss of body weight were compared in the Djungarian hamster (Phodopus sungorus campbelli). Hypothalamic neuropeptide Y (NPY) and gene expression for NPY and corticotropin-releasing factor (CRF) were examined after withdrawal of food for 48 h or exposure to short photoperiod for 10 or 20 wk.
B Beck +5 more
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NPY, NPY receptors and DPPIV in innate immunity and autoimmune disorders
2005It is now well established that the immune system and the nervous system communicate functionally with each other [1]. A major pathway for the bidirectional interaction between the nervous and the immune system is provided by the sympathetic nervous system (SNS) [2].
Sammy Bedoui, Stephan von Hörsten
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Receptors for NPY in peripheral tissues
Life Sciences, 2000Neuropeptide Y (NPY) and its congeners, peptide YY (PYY) and the pancreatic polypeptide (PP), have a large spectrum of peripheral actions. NPY is found in peripheral neurons, co-localized or not with noradrenaline; PYY and PP are expressed in endocrine cells of the pancreas and in the intestine of vertebrates.
L.H. Pheng, Domenico Regoli
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