Results 1 to 10 of about 2,340,344 (315)

Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. [PDF]

Sci Adv, 2022
In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide (PP), four G protein–coupled receptors mediate multiple essential physiological processes, such as food intake, vasoconstriction, sedation ...
Tang T, Tan Q, Han S, Diemar A, Löbner K, Wang H, Schüß C, Behr V, Mörl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B.   +18 more
europepmc   +4 more sources

Placental Neuropeptide Y ( NPY) and NPY receptors expressions and serum NPY levels in preeclampsia. [PDF]

Exp Biol Med (Maywood), 2019
Neuropeptide Y (NPY) has been reported as a vasoconstrictive substance that might be associated with preeclampsia. NPY mediates different effects via its specific NPY receptors.
Klinjampa R, Sitticharoon C, Souvannavong-Vilivong X, Sripong C, Keadkraichaiwat I, Churintaraphan M, Chatree S, Lertbunnaphong T.   +7 more
europepmc   +5 more sources

Neuropeptide Y (NPY) metabolism by endopeptidase‐2 hinders characterization of NPY receptors in rat kidney [PDF]

British Journal of Pharmacology, 1991
Despite the observation of pharmacological responses to neuropeptide Y (NPY) in mammalian kidneys, there are species differences in the ease with which specific NPY binding sites can be demonstrated; we have investigated whether this can be explained by differential metabolism of NPY by a membrane‐bound peptidase. NPY receptors were identified on cell
J. S. Price, A. Kenny, N. Huskisson, M. Brown   +3 more
semanticscholar   +5 more sources

NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma. [PDF]

Experimental and Molecular Pathology, 2012
Neuropeptide Y (NPY) level is elevated in allergic asthmatic airways and activation of NPY receptor-1 (NPY-Y1) on antigen-presenting cells (APCs) is essential for T cell priming. Paradoxically, NPY-Y1 modulates hyper-responsiveness in T cells, suggesting a bimodal role for NPY in APCs and T cells.
T. Makinde, R. Steininger, D. Agrawal
semanticscholar   +3 more sources

NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and ...
Yan-Chuan Shi, Shu Lin, Iris P L Wong, Paul A Baldock, Aygul Aljanova, Ronaldo F Enriquez, Lesley Castillo, Natalie F Mitchell, Ji-Ming Ye, Lei Zhang, Laurence Macia, Ernie Yulyaningsih, Amy D Nguyen, Sabrina J Riepler, Herbert Herzog, Amanda Sainsbury   +15 more
doaj   +2 more sources

NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway [PDF]

Mediators of Inflammation, 2019
Accumulated evidences show that neuroinflammation play a pivotal role in the pathogenesis of depression. Neuropeptide Y (NPY) and its receptors have been demonstrated to have anti-inflammative as well as antidepressant effects.
Wenjiao Wang, Tao Xu, Xinyue Chen, Kemeng Dong, Chunkai Du, Jing Sun, Cuige Shi, Xiaoxiao Li, Yutao Yang, Hui Li, Zhi-Qing David Xu   +10 more
doaj   +2 more sources

Neuropeptide Y Boosts Intestinal Mucosal Immunity of Tilapia Infected with Streptococcus agalactiae by Reducing Inflammation and Oxidative Stress [PDF]

Animals
Neuropeptides and their corresponding receptors have been observed to play a significant role in modulating immune cell functions and epithelial barrier functions.
Yang Yu, Ziyan Liu, Mengyuan Zhou, Zexia Chen, Ran Cai, Chaowei Song, Meiqing Li, Tiansheng Zhu, Caiyun Sun, Wensheng Li   +9 more
doaj   +2 more sources

Appetite suppression based on selective inhibition of NPY receptors [PDF]

International Journal of Obesity, 2002
The aim of this review is to critically assess available evidence that blockade of the actions of NPY at one of the five NPY receptor subtypes represents an attractive new drug discovery target for the development of an appetite suppressant drug.Blockade of the central actions of NPY using anti-NPY antibodies, antisense oligodeoxynucleotides against ...
S. Chamorro, O. Della-Zuana, J. Fauchère, M. Félétou, J. Galizzi, N. Levens   +5 more
semanticscholar   +3 more sources

NPY and Gene Therapy for Epilepsy: How, When,... and Y

Frontiers in Molecular Neuroscience, 2021
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell proliferation, cardiovascular and metabolic function, pain and neuronal excitability.
Stefano Cattaneo, Stefano Cattaneo, Gianluca Verlengia, Gianluca Verlengia, Pietro Marino, Pietro Marino, Michele Simonato, Michele Simonato, Michele Simonato, Barbara Bettegazzi, Barbara Bettegazzi   +10 more
doaj   +2 more sources

NPY receptor subtype in the rabbit isolated ileum [PDF]

British Journal of Pharmacology, 1999
The purpose of this work was to verify the hypothesis that the rabbit ileum is a selective preparation for the NPY Y5 receptor by using new selective antagonists recently synthesized. Spontaneous contractions of the rabbit isolated ileum were recorded and binding experiments were performed in cells expressing the human NPY Y1, Y2, Y4 or Y5 receptor ...
Michel Félétou, Jean‐Paul Nicolas, Marianne Rodriguez, Philippe Beauverger, Jean‐Pierre Galizzi, Jean A. Boutin, J Duhault   +6 more
openalex   +4 more sources