Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. [PDF]
Sci Adv, 2022 In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide (PP), four G protein–coupled receptors mediate multiple essential physiological processes, such as food intake, vasoconstriction, sedation ...
Tang T +18 more
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Placental Neuropeptide Y ( NPY) and NPY receptors expressions and serum NPY levels in preeclampsia. [PDF]
Exp Biol Med (Maywood), 2019 Neuropeptide Y (NPY) has been reported as a vasoconstrictive substance that might be associated with preeclampsia. NPY mediates different effects via its specific NPY receptors.
Klinjampa R +7 more
europepmc +6 more sources
Multiple NPY Receptors Inhibit GABAA Synaptic Responses of Rat Medial Parvocellular Effector Neurons in the Hypothalamic Paraventricular Nucleus [PDF]
Endocrinology, 2002 We have recently shown that NPY and α-melanocyte-stimulating hormone, which potently induce or inhibit feeding, respectively, have opposing modulatory actions on GABAergic synapses in the medial parvocellular region of the paraventricular hypothalamic ...
N. Pronchuk
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NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. [PDF]
PLoS ONE, 2010 BACKGROUND: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and ...
Yan-Chuan Shi +15 more
doaj +2 more sources
Characterisation of Neuropeptide Y Receptor Subtypes by Synthetic NPY Analogues and by Anti-receptor Antibodies [PDF]
Molecules, 2001 Neuropeptide Y (NPY), a 36-mer neuromodulator, binds to the receptors Y1, Y2, Y4 and Y5 with nanomolar affinity. They all belong to the rhodopsin-like G-protein coupled, seven transmembrane helix spanning receptors.
Annette G. Beck-Sickinger +3 more
doaj +2 more sources
Neuropeptide Y modulates the electrical activity of subfornical organ neurons [PDF]
Current Research in NeurobiologyThe subfornical organ (SFO) is a sensory circumventricular organ, lacking a blood-brain barrier. It is well-recognized as a key center for detection and integration of osmotic, ionic and hormonal signals for maintenance of hydromineral balance and ...
Lauren Shute, Mark Fry
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The Journal of Poultry Science, 2001 Neuropeptide Y (NPY) is known to be an essential orexigenic signal in mammalian and avian brain. Since NPY receptors in the avian brain have not been clarified, to determine whether Y1 receptor or Y1-like receptor(s) mediates the orexigenic effect of NPY
Shin-ichi Kawakami +6 more
doaj +3 more sources
NPY and Gene Therapy for Epilepsy: How, When,... and Y
Frontiers in Molecular Neuroscience, 2021 Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell proliferation, cardiovascular and metabolic function, pain and neuronal excitability.
Stefano Cattaneo +10 more
doaj +2 more sources
Actions of NPY, and Its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State [PDF]
Journal of Neuroscience, 2014 The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes.
Lili Huang +7 more
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Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis [PDF]
Experimental and Molecular MedicineTanycytes are a pivotal component of the hypothalamic network that controls energy homeostasis. Despite their importance, the regulatory mechanisms governing tanycyte–neuron interactions in response to metabolic signals remain unexplored.
Nayoun Kim +3 more
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