Results 101 to 110 of about 2,285,473 (285)

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Effect of blockade of neuropeptide Y receptor on aortic intima-media thickness and adipose tissue characteristics in normal and obese mice [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Atherosclerosis is an important risk factor for coronary heart disease. Neuropeptide Y (NPY) and its receptors, located in peripheral tissue such as white adipose tissue, have been linked to obesity and fat storage.
Masoud Alasvand, Bahman Rashidi, Shaghayegh Haghjooy Javanmard, Majid Khazaei   +3 more
doaj  

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley   +1 more source

Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors

MedComm
Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily.
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan   +13 more
doaj   +1 more source

Topical application of the cold‐mimetic l‐menthol decreases wheel running without affecting the beneficial effects of voluntary exercise in mice

Experimental Physiology, EarlyView.
Abstract Topical application of l‐menthol, a pharmacological cold‐mimetic and agonist of the cold‐sensing receptor TRPM8 (transient receptor potential cation channel subfamily M member 8), has been shown to stimulate brown adipose tissue (BAT) thermogenesis and reduce weight gain in both obese and lean male mice, without affecting energy intake.
Annalaura Bellucci, Bradley J. Baranowski, Stewart Jeromson, Michael Akcan, Serena Trang, Meagan Arbeau, Hadil Alfares, Katelyn Eisner, David C. Wright   +8 more
wiley   +1 more source

Agonist and antagonist activities on human NPFF₂ receptors of the NPY ligands GR231118 and BIBP3226 [PDF]

, 2001
Catherine Mollereau, Christine Gouardères, Yvan Dumont, Masato Kotani, Michel Detheux, Henri Doods, Marc Parmentier, Rémi Quirion, Jean‐Marie Zajac   +8 more
openalex   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Expression of substance P, NPY and their Receptors Is Altered in Major Depression [PDF]

, 2022
Swapnali Barde, Julio Águila, Wen Zhong, Anna Solarz, Irene Mei, Josée Prud’homme, Miklós Palkovits, Gustavo Turecki, Jan Mulder, Mathias Uhlén, Corina Nagy, Naguib Mechawar, Eva Hedlund, Tomas Hökfelt   +13 more
openalex   +1 more source

Characterization of NTS‐to‐VTA projection neurons reveals higher‐order synaptic organization and distinct responsiveness to cholecystokinin

The Journal of Physiology, EarlyView.
Abstract figure legend Here we construct an anatomical map of brainstem projections to the ventral tegmental area (VTA) and investigate the neurochemical and neurophysiological nature of these VTA‐projecting nucleus of the solitary tract (NTS) neurons.
Caitlin R. Ritchey, David J. Rossi, James H. Peters   +2 more
wiley   +1 more source

Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function

Hippocampus, Volume 35, Issue 5, September 2025.
ABSTRACT The dorsal and ventral hippocampus have distinct processing properties, but it remains unclear if interneuron subtypes differ in connectivity along the dorsoventral axis. Oriens lacunosum‐moleculare (OLM) interneurons, identified by the Chrna2 gene, are known to regulate memory processes differently along this axis. OLMɑ2 cells bidirectionally
Angelica Thulin, Katharina Henriksson, Ingrid Nogueira, Klas Kullander   +3 more
wiley   +1 more source