Results 111 to 120 of about 2,340,344 (315)

mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain

JCI Insight, 2022
Neuropathic pain is a refractory condition that involves de novo protein synthesis in the nociceptive pathway. The mTOR is a master regulator of protein translation; however, mechanisms underlying its role in neuropathic pain remain elusive.
Lunhao Chen, Yaling Hu, Siyuan Wang, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Gao   +12 more
doaj   +1 more source

Steady-state energy balance in animal models of obesity and weight loss [PDF]

, 2016
Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry, Cassie, Nikki, Chen, Duan, Johannessen, Helene, Kulseng, Bård, Olsen, Magnus Kringstad, Takeuchi, Koji, Zhao, Chun-Mei   +7 more
core   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]

, 2017
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José, Elizondo Vega, Roberto, García Robles, María de los Ángeles, Martinez, Fernando, Millán, Carola, Ordenes, Patricio, Recabal, Antonia, Salgado, Magdiel, Sepúlveda, Fernando, Uranga, Romina Maria, Uribe, Elena   +10 more
core   +1 more source

Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges

Epilepsia, EarlyView.
Donald J. Phillips, Autumn S. Ivy, Samuel Guzman, Saman Hazany, Xiangmin Xu   +4 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Central NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks

Physiological Reports, 2017
Exposure of chicks to a high ambient temperature (HT) has previously been shown to increase neuropeptide Y (NPY) mRNA expression in the brain. Furthermore, it was found that NPY has anti‐stress functions in heat‐exposed fasted chicks.
Hatem M. Eltahan, Mohammad A. Bahry, Hui Yang, Guofeng Han, Linh T. N. Nguyen, Hiromi Ikeda, Mohamed N. Ali, Khairy A. Amber, Mitsuhiro Furuse, Vishwajit S. Chowdhury   +9 more
doaj   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor

Frontiers in Pharmacology, 2019
G protein-coupled receptors (GPCRs) represent a large family of different proteins, which are involved in physiological processes throughout the entire body. Furthermore, they represent important drug targets. For rational drug design, it is important to
Lisa Maria Kögler, Jan Stichel, Anette Kaiser, Annette G. Beck-Sickinger   +3 more
doaj   +1 more source

Double labelling immunohistochemical characterization of autonomic sympathetic neurons innervating the sow retractor clitoridis muscle [PDF]

, 2008
Retrograde neuronal tracing and immunohistochemical methods were used to define the neurochemical content of sympathetic neurons projecting to the sow retractor clitoridis muscle (RCM). Differently from the other smooth muscles of genital organs, the RCM
Acone, Franca, Bo Minelli, Luisa, Botti, Maddalena, Gazza, Ferdinando, Palmieri, Giovanni, Panu, Rino, Ragionieri, Luisa   +6 more
core