Results 121 to 130 of about 2,340,344 (315)
Epilepsia, EarlyView.Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed +8 more
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Obesity in the Otsuka Long Evans Tokushima Fatty Rat: Mechanisms and Discoveries [PDF]
, 2016 Understanding the neural systems underlying the controls of energy balance has been greatly advanced by identifying the deficits and underlying mechanisms in rodent obesity models.
Sheng Bi, Timothy H. Moran
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Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, EarlyView.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
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International Journal of General Medicine, 2010 Pallab K GangulyCollege of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi ArabiaAbstract: Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior.
Pallab K Ganguly
doaj
Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures [PDF]
, 2003 Glutamate and NPY have been implicated in hippocampal neuropathology in temporal lobe epilepsy. Thus, we investigated the involvement of NPY receptors in mediating neuroprotection against excitotoxic insults in organotypic cultures of rat hippocampal ...
Carvalho, Arsélio P. +6 more
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Journal of Sleep Research, EarlyView.How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads +8 more
wiley +1 more source
Cell Reports, 2013 Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate neuronal primary cilia in regulation of energy homeostasis. Cilia in hypothalamic neurons have been hypothesized to sense and regulate systemic energy status, but the ...
Alexander V. Loktev, Peter K. Jackson
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Increased novelty-induced motor activity and reduced depression-like behavior in NPY Y4 receptor knockout mice [PDF]
, 2008 Ramon Tasan +5 more
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Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice [PDF]
, 2017 Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are
Bake, T. +4 more
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Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception
Orthodontics &Craniofacial Research, EarlyView.ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
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