NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma. [PDF]
Experimental and Molecular Pathology, 2012 Neuropeptide Y (NPY) level is elevated in allergic asthmatic airways and activation of NPY receptor-1 (NPY-Y1) on antigen-presenting cells (APCs) is essential for T cell priming. Paradoxically, NPY-Y1 modulates hyper-responsiveness in T cells, suggesting a bimodal role for NPY in APCs and T cells.
T. Makinde, R. Steininger, D. Agrawal
semanticscholar +3 more sources
Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY–Y2 receptor [PDF]
Peptides, 2007 The rat glucocorticoid-induced receptor (rGIR) is an orphan G protein-coupled receptor awaiting pharmacological characterization. Among known receptors, rGIR exhibits highest sequence similarity to the neuropeptide Y (NPY)-Y(2) receptor (38-40%). The pharmacological profile of rGIR was investigated using (125)I-PYY(3-36), a Y(2)-preferring radioligand ...
Renu Sah +5 more
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PET Imaging of the Neuropeptide Y System: A Systematic Review
Molecules, 2022 Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca +3 more
doaj +1 more source
Depressor Effect of Intrathecal Neuropeptide Y (NPY) Is Mediated by Y2 Subtype of NPY Receptors
Journal of Cardiovascular Pharmacology, 1993 The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors produced a dose-related depressor ...
Xiaoli Chen, Thomas C. Westfall
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Appetite suppression based on selective inhibition of NPY receptors [PDF]
International Journal of Obesity, 2002 The aim of this review is to critically assess available evidence that blockade of the actions of NPY at one of the five NPY receptor subtypes represents an attractive new drug discovery target for the development of an appetite suppressant drug.Blockade of the central actions of NPY using anti-NPY antibodies, antisense oligodeoxynucleotides against ...
S. Chamorro +5 more
semanticscholar +3 more sources
Neuropeptide Y (NPY) metabolism by endopeptidase‐2 hinders characterization of NPY receptors in rat kidney [PDF]
British Journal of Pharmacology, 1991 Despite the observation of pharmacological responses to neuropeptide Y (NPY) in mammalian kidneys, there are species differences in the ease with which specific NPY binding sites can be demonstrated; we have investigated whether this can be explained by differential metabolism of NPY by a membrane‐bound peptidase. NPY receptors were identified on cell
J. S. Price +3 more
semanticscholar +4 more sources
Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats. [PDF]
PLoS ONE, 2012 Neuropeptide Y (NPY) plays an important role in regulating appetite and hunger in vertebrates. In the hypothalamus, NPY stimulates food intake under the control of the nutritional status.
Julia Negroni +6 more
doaj +1 more source
Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS
Brain Sciences, 2021 Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is the ...
Courtney M. Clark +5 more
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Structural basis of neuropeptide Y signaling through Y1 receptor
Nature Communications, 2022 The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park +12 more
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Detection of endogenous NPY release determined by novel GRAB sensor in cultured cortical neurons
Frontiers in Cellular Neuroscience, 2023 Neuropeptide Y (NPY) is an abundantly expressed peptide in the nervous system. Its widespread distribution along with its receptors, both centrally and peripherally, indicates its broad functions in numerous biological processes.
Emma Kragelund Christensen +8 more
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