Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS
Brain Sciences, 2021 Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is the ...
Courtney M. Clark +5 more
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Structural basis of neuropeptide Y signaling through Y1 receptor
Nature Communications, 2022 The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park +12 more
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Detection of endogenous NPY release determined by novel GRAB sensor in cultured cortical neurons
Frontiers in Cellular Neuroscience, 2023 Neuropeptide Y (NPY) is an abundantly expressed peptide in the nervous system. Its widespread distribution along with its receptors, both centrally and peripherally, indicates its broad functions in numerous biological processes.
Emma Kragelund Christensen +8 more
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The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice [PDF]
Journal of Integrative Neuroscience, 2022 Insulin is known to act in the central nervous system to regulate several physiological and behavioural outcomes, including energy balance, glucose homeostasis and cognitive functioning. However, the neuronal populations through which insulin enhances
Elisabeth K. Goodman +8 more
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Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]
, 2018 Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella +13 more
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Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors
Neurobiology of Disease, 2005 Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selective agonists and antagonists.
David P.D. Woldbye +7 more
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Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. [PDF]
PLoS ONE, 2013 Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD ...
Barbara Sigala +11 more
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Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]
, 2019 The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan +9 more
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Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]
, 2017 The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
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Ancient grandeur of the vertebrate neuropeptide Y system shown by the coelacanth Latimeria chalumnae
Frontiers in Neuroscience, 2013 The neuropeptide Y (NPY) family receptors and peptides have previously been characterized in several tetrapods, teleost fishes and in a holocephalan cartilaginous fish.
Dan eLarhammar, Christina A Bergqvist
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