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Therapeutic potential of neuropeptide Y (NPY) receptor ligands [PDF]
EMBO Molecular Medicine, 2010 Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. Since its discovery, NPY has been implicated in metabolic regulation and, although interest in its role in central mechanisms related to food intake and obesity has somewhat diminished, the topic remains a strong focus of research ...
Brothers, Shaun P, Wahlestedt, Claes
openaire +2 more sources
Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
wiley +1 more source
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors
Neurobiology of Disease, 2005 Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selective agonists and antagonists.
David P.D. Woldbye +7 more
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Cell Communication and Signaling, 2019 Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context.
Miron Mikhailowitsch Gershkovich +3 more
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Effects of neuropeptide Y on electrical activity and myocardial contractility
Учёные записки Казанского университета: Серия Естественные науки, 2018 Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev +6 more
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PLoS ONE, 2015 The increased proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in pathophysiological remodeling of arteries during hypertension in pregnancy. However, the mechanisms involved in this process remain unclear.
Ping Zhang +8 more
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ARCAgRP/NPY Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice
Frontiers in Physiology, 2020 While much is known about the role of agouti-regulated peptide/neuropeptide Y (AgRP/NPY) and pro-opiomelanocortin (POMC) neurons to regulate energy homeostasis, little is known about how forced energy expenditure, such as exercise, modulates these ...
Wyatt Bunner +21 more
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Veterinární Medicína, 2003 The objective of this study was to determine whether α-adrenergic receptors are involved in the contractile activity of neuropeptide Y (NPY) in the porcine isolated ovarian artery collected from immature pigs and from the animals on day 1-5, 8-13 and 17 ...
W. Markiewicz
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Avian Neuropeptide Y: Beyond Feed Intake Regulation
Veterinary Sciences, 2022 Neuropeptide Y (NPY) is one of the most abundant and ubiquitously expressed neuropeptides in both the central and peripheral nervous systems, and its regulatory effects on feed intake and appetite- have been extensively studied in a wide variety of ...
Elizabeth S. Greene +3 more
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NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium
Neurobiology of Disease, 2010 In the CNS, ATP is released upon injury and promotes neuroproliferation via purinergic receptors. In the olfactory epithelium, ATP promotes the synthesis and release of neurotrophic factor NPY in neonates and induces neuroproliferation in neonatal and ...
Cuihong Jia, Colleen Cosgrove Hegg
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