Results 71 to 80 of about 2,285,473 (285)

Central NPY‐Y5 sub‐receptor partially functions as a mediator of NPY‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks

Physiological Reports, 2017
Exposure of chicks to a high ambient temperature (HT) has previously been shown to increase neuropeptide Y (NPY) mRNA expression in the brain. Furthermore, it was found that NPY has anti‐stress functions in heat‐exposed fasted chicks.
Hatem M. Eltahan, Mohammad A. Bahry, Hui Yang, Guofeng Han, Linh T. N. Nguyen, Hiromi Ikeda, Mohamed N. Ali, Khairy A. Amber, Mitsuhiro Furuse, Vishwajit S. Chowdhury   +9 more
doaj   +1 more source

Protective Effects of Human Milk Oligosaccharides (hMOs) on Analgesic, Nonsteroidal Anti‐inflammatory Drugs (NSAIDs)‐Induced Disruption of Gut Barrier Integrity in Cocultures Mimicking Neuro‐Gut Epithelial Cell Crosstalk

Molecular Nutrition &Food Research, EarlyView.
Nerve cells partially mitigate indomethacin‐induced tight junction dysregulation in neuro‐gut epithelial cell cocultures. Human milk oligosaccharides 2′‐ and 3‐fucosyllactose (2′‐FL and 3‐FL) protect the neuro‐gut epithelial barrier from indomethacin‐induced damage. This protection is stronger in cocultures with higher nerve cell densities.
Xiaochen Chen, Naschla Gasaly, Marthe T. C. Walvoort, Paul de Vos   +3 more
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor

Frontiers in Pharmacology, 2019
G protein-coupled receptors (GPCRs) represent a large family of different proteins, which are involved in physiological processes throughout the entire body. Furthermore, they represent important drug targets. For rational drug design, it is important to
Lisa Maria Kögler, Jan Stichel, Anette Kaiser, Annette G. Beck-Sickinger   +3 more
doaj   +1 more source

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions

The Journal of Pathology, EarlyView.
Abstract High‐risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single‐cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about local signaling dynamics.
Joachim T Siaw, Peter Merseburger, Marcus Borenäs, Caroline Jansson, Jenny Karlsson, Arne Claeys, Eva Jennische, Dan E Lind, David Gisselsson Nord, Ruth H Palmer, Jimmy Van den Eynden   +10 more
wiley   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, EarlyView.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source

Altered function of arcuate leptin receptor expressing neuropeptide Y neurons depending on energy balance

Molecular Metabolism, 2023
Objective: One of leptin's main targets in the hypothalamus are neuropeptide Y (NPY) neurons, with selective deletion of leptin receptors (Lepr) specifically in Npy neurons resulting in major alterations of energy partitioning between fat and bone mass ...
Nicola J. Lee, Jennifer Oraha, Yue Qi, Ronaldo F. Enriquez, Ramon Tasan, Herbert Herzog   +5 more
doaj  

Effects of glucagon‐like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon‐like peptide 1 agonists (GLP‐1RAs) are a recently introduced class of antidiabetic drugs with powerful weight‐loss effect; this may induce an indirect positive effect on the testicular function ...
Gianmaria Salvio, Alessandro Ciarloni, Nicola Ambo, Monia Bordoni, Michele Perrone, Silvia Rossi, Giancarlo Balercia   +6 more
wiley   +1 more source

Neuropeptide Y level in paraventricular nucleus of experimental diabetic rats: correlation with sympathetic activity and body weight

International Journal of General Medicine, 2010
Pallab K GangulyCollege of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi ArabiaAbstract: Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior.
Pallab K Ganguly
doaj  

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia

Cell Reports, 2013
Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate neuronal primary cilia in regulation of energy homeostasis. Cilia in hypothalamic neurons have been hypothesized to sense and regulate systemic energy status, but the ...
Alexander V. Loktev, Peter K. Jackson
doaj   +1 more source