Results 81 to 90 of about 2,285,473 (285)

A GLP‐1R/Y1 receptor/Y2 receptor triple agonist decreases fentanyl‐evoked dopamine release in the nucleus accumbens and attenuates fentanyl taking and seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey, Enzo Lavecchia, Kylie S. Chichura, Matthew R. Hayes, Robert P. Doyle, Heath D. Schmidt   +5 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Neurobeachin (NBEA) is a novel gene associated with GLP‐1 receptor agonist associated weight loss

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are promising interventions for weight loss, but their efficacy varies significantly across individuals.
Arshiya Mariam‐Smith, Joseph H. Breeyear, Noah J. Daniels, Kevin M. Pantalone, Marcio L. Griebeler, Alison A. Motsinger‐Reif, Daniel M. Rotroff   +6 more
wiley   +1 more source

The murine NPY‐1 receptor gene Structure and delineation of tissue‐specific expression [PDF]

, 1992
Carola Eva, Alessandra Oberto, Rolf Sprengel, E Genazzani   +3 more
openalex   +1 more source

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single‐nucleus multiomics

Epilepsia, EarlyView.
Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão, Manuela Lemoine, Ludmyla Kandratavicius, Clarissa L. Yasuda, Marina K. M. Alvim, Enrico Ghizoni, Ingmar Blümcke, Fernando Cendes, Fabio Rogerio, Iscia Lopes‐Cendes, Diogo F. T. Veiga   +10 more
wiley   +1 more source

Quantitative receptor radioautography in the study of receptor-receptor interactions in the nucleus tractus solitarii

Brazilian Journal of Medical and Biological Research, 1998
The nucleus tractus solitarii (NTS) in the dorsomedial medulla comprises a wide range of neuropeptides and biogenic amines. Several of them are related to mechanisms of central blood pressure control.
Fior-Chadi D.R., Fuxe K.
doaj  

Functional effects and ligand binding of chimeric galanin‐neuropeptide Y (NPY) peptides on NPY and galanin receptor types [PDF]

, 1994
Ulrika Kahl, Ülo Langel, Tamás Bartfai, Lars Grundemar   +3 more
openalex   +1 more source

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo, Erik J. Fleischel, Dipan C. Patel, Harald Sontheimer   +3 more
wiley   +1 more source

Cell type specificity of neurovascular coupling in cerebral cortex

eLife, 2016
Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of ...
Hana Uhlirova, Kıvılcım Kılıç, Peifang Tian, Martin Thunemann, Michèle Desjardins, Payam A Saisan, Sava Sakadžić, Torbjørn V Ness, Celine Mateo, Qun Cheng, Kimberly L Weldy, Florence Razoux, Matthieu Vandenberghe, Jonathan A Cremonesi, Christopher GL Ferri, Krystal Nizar, Vishnu B Sridhar, Tyler C Steed, Maxim Abashin, Yeshaiahu Fainman, Eliezer Masliah, Srdjan Djurovic, Ole A Andreassen, Gabriel A Silva, David A Boas, David Kleinfeld, Richard B Buxton, Gaute T Einevoll, Anders M Dale, Anna Devor   +29 more
doaj   +1 more source

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source