Results 141 to 150 of about 33,318 (195)

Impact of NQO1 dysregulation in CNS disorders

Journal of Translational Medicine
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous ...
Li Yuhan, Maryam Khaleghi Ghadiri, Ali Gorji   +2 more
doaj   +1 more source

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif, MD Nazmul Hasan, Nobuhiro Nozaki, Yutaro Ide, Yoshiyuki Akiyama, Shaohsu Wang, Most Shumi Akhter Shathi, Osamu Yamato, Naoki Miura   +8 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Targeting Inflammatory and Oxidative Pathways in Idiopathic Pulmonary Fibrosis: Synergistic Effects of Quercetin and Pirfenidone in Modulating Nrf2/PPAR‐γ and TLR‐4/NF‐κB Pathways

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
Pirfenidone (Pirf) and Quercetin (Quer) both reduced inflammation, oxidative stress, and fibrosis in a bleomycin‐induced pulmonary fibrosis model, with Quer showing a stronger effect than Pirf. The combination of Pirf and Quer provided enhanced anti‐fibrotic and anti‐inflammatory benefits, suggesting potential for improved therapeutic strategies in ...
Hanaa Wanas, Amira Karam Khalifa, Hossein M. Elbadawy, Amany E. Hamoud, Mohannad A. Almikhlafi, Emad Ali Albadawi, Hadel Mahroos Alghabban, Wejdan Hussain Owaydhah, Amr M. Galal   +8 more
wiley   +1 more source

The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2–ARE Pathway in C57BL/6J Mice

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Stress‐induced hair depigmentation is closely associated with neurogenic oxidative stress and dysfunction of melanocyte stem cells. Activation of antioxidant defense pathways, particularly the Nrf2–ARE pathway, may protect melanocytes from oxidative damage.
Jingbo Cui, Linxia Duan, Hui Qu, Jing Ning, Zhi Li, Huihua Zhang   +5 more
wiley   +1 more source

NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer. [PDF]

J Natl Cancer Inst
Williams D, Patel C, Murray K, Oldfield L, Small B, Barrera LN, O'Sullivan R, Birch-Ford J, Evans A, Campbell F, Perez-Mancera PA, Halloran CM, Palmer D, Greenhalf W, Copple IM, Goldring C, Hackert T, Jackson R, Neoptolemos JP, Springfeld C, Büchler MW, Michalski CW, Ghaneh P, Costello E.   +23 more
europepmc   +1 more source

Systems biology can provide guidance to synthetic biology in the pursuit of new drug targets. [PDF]

Front Pharmacol
Voit EO.
europepmc   +1 more source

Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug. [PDF]

Proc Natl Acad Sci U S A
Antonucci L, Watari K, Feng Y, Qi J, Zhu M, Wang T, Ng I, Vucic EA, Riahi I, Huang L, Hosseini M, Mose E, French R, Weitz J, Bar-Sagi D, Dawson DW, Sun B, Tiriac H, Xu J, Xu S, Lowy AM, Karin M.   +21 more
europepmc   +1 more source

A comprehensive multi-omics and functional study of evolutionary adaptive responses to smoke. [PDF]

iScience
Pouwels SD, Chen H, Rathnayake SNH, Lan A, Mahbub RM, Yeung ACY, Brandsma CA, Lobo TJ, Guryev V, Heijink IH, van den Berge M, Faiz A.   +11 more
europepmc   +1 more source