Results 141 to 150 of about 200,244 (343)

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells. [PDF]

, 2017
Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood.
Glass, Christopher K, Hadeli, Nizar K, Hogan, Nicholas T, Lam, Michael T, Romanoski, Casey E, Springstead, James R, Stolze, Lindsey K, Whalen, Michael B   +7 more
core   +2 more sources

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]

, 2016
Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F., Lowes, D. A., McCreath, G., Scullion, M. M. F., Webster, N. R.   +4 more
core   +1 more source

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2 [PDF]

, 2014
Shasha Tao, Shue Wang, Seyed Javad Moghaddam, Aikseng Ooi, Eli Chapman, Pak Kin Wong, Donna D. Zhang   +6 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Naringin protects against diabetic cataracts in rats by modulating oxidative stress and inflammation [PDF]

Archives of Biological Sciences
This study investigated the efficacy of naringin, a bioflavonoid recognized for its antioxidative and anti-inflammatory properties, in preventing the development of diabetic cataracts.
Meng Gaoqiang, Meng Li, Xu Yalong
doaj   +1 more source

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents [PDF]

, 2019
Ziwen Wang, Zelin Chen, Zhongyong Jiang, Peng Luo, Lang Liu, Yu Huang, Huilan Wang, Yu Wang, Lei Long, Xu Tan, Dengqun Liu, Taotao Jin, Yawei Wang, Yang Wang, Fengying Liao, Chi Zhang, Long Chen, Yibo Gan, Yunsheng Liu, Fan Yang, Chunji Huang, Hongming Miao, Jieping Chen, Tianmin Cheng, Xiaobing Fu, Chunmeng Shi   +25 more
openalex   +1 more source

Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells [PDF]

, 2022
Mengling Zhang, Hongmei Qiu, Lejiao Mao, Bin Wang, Na Li, Yinzhen Fan, Ping Weng, Siyao Hu, Xiaomei Dong, Xia Qin, Chengzhi Chen, Zhen Zou, Chao Yu, Jun Zhang   +13 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The Efficacy of Administering Fruit-Derived Polyphenols to Improve Health Biomarkers, Exercise Performance and Related Physiological Responses [PDF]

, 2019
open access articlePolyphenols are secondary metabolites involved in a myriad of critical processes in plants. Over recent decades, special attention has been paid to the anti-oxidative role of fruit-derived polyphenols in the human diet, with evidence ...
Bailey, Stephen, Da Boit, Mariasole, Higgins, Matthew, Kashi, Daniel, Shabir, Akbar   +4 more
core   +1 more source