Results 261 to 270 of about 197,106 (353)

Ellagic Acid Enhances RSL3-Induced Ferroptosis by Inhibiting the Nrf2/HO-1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma. [PDF]

FASEB J
Bai J, Dai Y, Ein Oon C, Hu P, Luo J, Han J, Yang L, Bostani A, Fei Z, Jin Y.   +9 more
europepmc   +1 more source

Nrf2 to the Rescue [PDF]

Epilepsy Currents, 2015
openaire   +2 more sources

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

NRF2-mediated ferroptosis suppression defines a cancer-specific vulnerability in tumors. [PDF]

Redox Biol
Huang D, Zhang M, Stansfield BN, Ahmed M, Xu T, Alexander L, Anandhan A, Ma M, Liu P, Yang-Hartwich Y, Fang D, Chapman E, Garcia JGN, Wong PK, Ooi A, Zhang DD.   +15 more
europepmc   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease. [PDF]

MedComm (2020)
Wang W, Jiang X, Qiu R, Wijaya CS, Chen M, Wang J, Zhu L, Jin H, Feng L.   +8 more
europepmc   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Melatonin Alleviates Diabetic Cardiomyopathy by Inhibiting Cellular Senescence via Activation of the MT2/SIRT1/Nrf2 Signaling Pathway. [PDF]

J Pineal Res
Liu F, Zhong A, Li J, Sun Q, Fan X, Fan W, Tong X, Liang Y, Wang X, Huang D, Zhang Y, Gao F, Lu B, Wang B.   +13 more
europepmc   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source