Results 241 to 250 of about 197,106 (353)

Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2. [PDF]

Redox Biol
Sznarkowska A, Urban-Wójciuk Z, Dziadosz-Brzezińska A, Cieśla M, Kusiński S, Wakimian K, Szabelska-Beręsewicz A, Chruściel E, Papak I, Marek-Trzonkowska N, Piróg A, Rzyman W.   +11 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Nrf2-Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias. [PDF]

J Biochem Mol Toxicol
Irfan M, Taha M, Asghar SMF, Raza M.
europepmc   +1 more source

Metabolite Profiles and Antioxidant Activity of Dendrobium catenatum Under Simulated Wild Cultivation

Food Safety and Health, EarlyView.
Dendrobium catenatum grown under simulated wild cultivation showed significantly higher flavonoids and stilbenes, leading to enhanced antioxidant activity in both leaves and stems compared to facility‐grown plants. Integrated metabolomics, antioxidant assays, and network pharmacology identified Denbinobin as a key multi‐target antioxidant compound ...
Chuyun Guan, Yixin Tang, Qiaoxian Yu, Yanghui Shen, Ying Shi, Pan Wang, Jinping Si, Jingjing Liu   +7 more
wiley   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

<i>Caenorhabditis elegans</i> as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer's Disease: Plant Bioactive Compounds and Therapeutic Translation. [PDF]

Int J Mol Sci
Bellver-Sanchis A, Ralchev NR, Romanska PR, Dyakova NK, Ivanova KI, Griñán-Ferré C, Marchev AS.   +6 more
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Astragaloside IV confers vascular protection after traumatic brain injury through an Nrf2-dependent mechanism involving VWF. [PDF]

IBRO Neurosci Rep
Feng S, Sun B, Li M, Tian L, Sun G.
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

NRF2 activation is required for chemotherapy resistance acquisition in medulloblastoma via metabolic and redox adaptation. [PDF]

Redox Biol
Manfreda L, Rruga F, Zanolli A, Marzullo BP, Vettore L, Mozzo M, Canton M, Marchioro C, Rampazzo E, Mariotto E, Filiberti S, Turati M, Ronca R, Tennant DA, Persano L, Viola G, Bortolozzi R.   +16 more
europepmc   +1 more source