Results 221 to 230 of about 108,098 (261)
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Archives of Pharmacal Research, 2020
White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism.
Zhendi, Wang +8 more
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White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism.
Zhendi, Wang +8 more
openaire +2 more sources
Biochemistry (Moscow), 2017
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov +5 more
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Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov +5 more
openaire +2 more sources
The Dual Roles of NRF2 in Cancer
Trends in Molecular Medicine, 2016NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that ...
Menegon, S +2 more
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NRF2 activation in cancer and overview of NRF2 small molecule inhibitors
Archives of Pharmacal ResearchNRF2 is a redox-sensitive transcription factor that activates the expression of phase II detoxifying and antioxidant enzymes. In addition to maintaining redox homeostasis, NRF2 regulates various other processes, including metabolism, stem cell renewal, mitochondrial function, and proteostasis.
Hoang Hai Ngo +4 more
openaire +2 more sources
2011
Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
openaire +1 more source
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
Cancer Cell, 2021Yuan Liu, Avi Kumar, Laura Antonucci
exaly
Biochemical Society. Transactions, 2015
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
openaire +1 more source
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
openaire +1 more source
2022
Breast cancer is still one of the leading cause of morality in women. Despite of all measures for early detection and prevention, there is no significant progress in the survival rates. One of the reasons for this is therapy resistance. Aquaporins, firstly described as cellular plumbing system, provided mechanisms for cancer cell motility and ...
openaire
Breast cancer is still one of the leading cause of morality in women. Despite of all measures for early detection and prevention, there is no significant progress in the survival rates. One of the reasons for this is therapy resistance. Aquaporins, firstly described as cellular plumbing system, provided mechanisms for cancer cell motility and ...
openaire