Results 211 to 220 of about 108,098 (261)
The Role and Mechanism of Nrf2 in Ameliorating Oxidative Stress and Inflammation in IR Mice by Aerobic Exercise. [PDF]
Int J Mol SciLiu X +5 more
europepmc +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati +6 more
wiley +1 more source
Cafestol ameliorates diabetic nephropathy via Keap1-Nrf2 axis activation: A novel renoprotective mechanism independent of glycemic control. [PDF]
PLoS OneSinan NA, Almujaydil MS.
europepmc +1 more source
Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP-Induced Mouse Model of Parkinson's Disease. [PDF]
CNS Neurosci TherMei M +6 more
europepmc +1 more source
Roxadustat attenuates contrast-induced acute kidney injury potentially mediated via the Nrf2/HO-1 signaling pathway. [PDF]
Ren FailWang J, E JW, Zhang J.
europepmc +1 more source
NRF2 and the Hallmarks of Cancer [PDF]
Cancer Cell, 2018 The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy.
Eli Chapman +2 more
exaly +3 more sources
Transcriptional Regulation by Nrf2
Antioxidants and Redox Signaling, 2018 Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.
Iok In Christine Chio +2 more
exaly +4 more sources
Regulation of Nrf2—an update [PDF]
Free Radical Biology and Medicine, 2014 Nrf2:INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is a nuclear factor that controls the expression and coordinated induction of a battery of genes that encode detoxifying enzymes, drug transporters, antiapoptotic proteins, and proteasomes.
Raju Ghimire +2 more
exaly +3 more sources