Results 311 to 320 of about 197,106 (353)

Mazes of Nrf2 regulation

Biochemistry (Moscow), 2017
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov, P M, Kozhin, A V, Chechushkov, G G, Martinovich, N V, Kandalintseva, E B, Menshchikova   +5 more
openaire   +2 more sources

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Food & Function, 2021
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD.
Jing-Da Li, Tianqi Wang, Panpan Liu, Fuyuan Yang, Xu-Dong Wang, Wei-Long Zheng, Wen-Long Sun   +6 more
semanticscholar   +1 more source

Insights into the molecular mechanisms, structure-activity relationships and application prospects of polysaccharides by regulating Nrf2-mediated antioxidant response.

Carbohydrate Polymers
The occurrence and development of many diseases are closely related to oxidative stress. In this context, accumulating evidence suggests that Nrf2, as the master switch of cellular antioxidant signaling, plays a central role in controlling the expression
Nuo Chen, Meifen Hu, Tingyue Jiang, Ping Xiao, Jin-Ao Duan   +4 more
semanticscholar   +1 more source

NRF2 activation in cancer and overview of NRF2 small molecule inhibitors

Archives of Pharmacal Research
NRF2 is a redox-sensitive transcription factor that activates the expression of phase II detoxifying and antioxidant enzymes. In addition to maintaining redox homeostasis, NRF2 regulates various other processes, including metabolism, stem cell renewal, mitochondrial function, and proteostasis.
Hoang Hai Ngo, Bo-Yeong Yu, Jeong-Eun Lee, Hyunwoo Kim, Young-Sam Keum   +4 more
openaire   +2 more sources

NRF2 and chemoprevention

2011
Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
openaire   +1 more source

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

Biochemical and Biophysical Research Communications - BBRC, 1997
K. Itoh, T. Chiba, Satoru Takahashi, T. Ishii, Kazuhiko Igarashi, Y. Katoh, T. Oyake, N. Hayashi, K. Satoh, I. Hatayama, Masayuki Yamamoto, Y. Nabeshima   +11 more
semanticscholar   +1 more source

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

Annual Review of Pharmacology and Toxicology, 2007
T. Kensler, N. Wakabayashi, S. Biswal
semanticscholar   +1 more source

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

Cancer Cell, 2021
Yuan Liu, Avi Kumar, Laura Antonucci
exaly  

Peroxiporins and NRF2

2022
Breast cancer is still one of the leading cause of morality in women. Despite of all measures for early detection and prevention, there is no significant progress in the survival rates. One of the reasons for this is therapy resistance. Aquaporins, firstly described as cellular plumbing system, provided mechanisms for cancer cell motility and ...
openaire  

Thirty years of NRF2: advances and therapeutic challenges

Nature reviews. Drug discovery
Donna D. Zhang
semanticscholar   +1 more source