Results 71 to 80 of about 115,081 (308)

Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [PDF]

, 2019
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral ...
Amatore, D, Brundu, S, Celestino, I, Checconi, P, Coluccio, P, Fraternale, A, Galluzzi, L, Magnani, M, Nencioni, L, Palamara, A. T.   +9 more
core   +1 more source

Pau d’arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway

The Journal of Toxicological Sciences, 2014
Pau d'arco is a plant-derived traditional medicine that acts by poorly understood molecular mechanisms. Here, we studied the effect of pau d'arco on the cytoprotective transcription factor Nrf2. An aqueous extract of pau d'arco stimulated Nrf2-dependent gene expression and led to nuclear localization of Nrf2 in vitro.
Michelle, Richter, Angelika F, Winkel, Dietmar, Schummer, Martin, Gerlitz, Meltsje, de Hoop, Bodo, Brunner, Maike, Glien, Dieter, Schmoll   +7 more
openaire   +3 more sources

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2 [PDF]

Journal of Biological Chemistry, 1999
Exposure of HepG2 cells to beta-naphthoflavone (beta-NF) or pyrrolidine dithiocarbamate (PDTC) resulted in the up-regulation of the gamma-glutamylcysteine synthetase catalytic (GCS(h)) and regulatory (GCS(l)) subunit genes. Increased expression was associated with an increase in the binding of Nrf2 to electrophile response elements (EpRE) in the ...
A C, Wild, H R, Moinova, R T, Mulcahy
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]

, 2015
Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana, Feng, Xuli, Kim, Hyun, Lee, Kunwoo, Lingampalli, Nithya, Lo Sterzo, Carlo, Murthy, Niren, Rafi, Mohammad, Tang, Richard, Wang, Xiaojian   +9 more
core   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Journal of Hematology & Oncology, 2016
Background The objective of this study was to evaluate the effect of platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer cell lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations ...
Yijun Tian, Kongming Wu, Qian Liu, Na Han, Li Zhang, Qian Chu, Yuan Chen   +6 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. [PDF]

PLoS Pathogens, 2014
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS) and primary effusion B-cell lymphoma. KSHV induces reactive oxygen species (ROS) early during infection of human dermal microvascular endothelial (HMVEC-d ...
Olsi Gjyshi, Virginie Bottero, Mohanan Valliya Veettil, Sujoy Dutta, Vivek Vikram Singh, Leela Chikoti, Bala Chandran   +6 more
doaj   +1 more source

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction [PDF]

, 2010
Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance.
Adenuga, Adenuga, Barnes, David Adenuga, Garbin, Goven, Harju, Hew, Hongwei Yao, Irfan Rahman, Isaac K. Sundar, Ito, Ito, Itoh, Jae-Woong Hwang, Jaiswal, Keatings, Kramer, Liu, Malhotra, Marwick, Rahman, Rangasamy, Samuel Caito, Sangwoon Chung, Southam, Sun, Tomaki, Trivedi, Yang, Yang, Yao, Yao, Zimmermann   +33 more
core   +1 more source

NRF2 Shortage in Human Skin Fibroblasts Dysregulates Matrisome Gene Expression and Affects Collagen Fibrillogenesis

Journal of Investigative Dermatology, 2023
NRF2 is a master regulator of the antioxidative response that was recently proposed as a potential regulator of extracellular matrix (ECM) gene expression. Fibroblasts are major ECM producers in all connective tissues, including the dermis. A better understanding of NRF2-mediated ECM regulation in skin fibroblasts is thus of great interest for skin ...
Mélanie Salamito, Benjamin Gillet, Delfien Syx, Elisabeth Vaganay, Marilyne Malbouyres, Catherine Cerutti, Nicolas Tissot, Chloé Exbrayat-Héritier, Philippe Perez, Christophe Jones, Sandrine Hughes, Fransiska Malfait, Valérie Haydont, Sibylle Jäger, Florence Ruggiero   +14 more
openaire   +5 more sources