Results 171 to 180 of about 92,684 (262)

MiR-200a-3p protects against myocardial ischemia-reperfusion injury via KEAP1-NRF2 signaling. [PDF]

Front Physiol
Zhao Y, Liu L, Shen X, Wang M, Wang M, Sun L, Zhang K.   +6 more
europepmc   +1 more source

Liposomal Nano-Curcumin Attenuates Cisplatin-Induced Hepatotoxicity in Rats with Concomitant Regulation of Wnt/β-Catenin/GSK-3β and Nrf2 Signaling. [PDF]

Biomedicines
Alqahtani QH, Atteya M, Al-Matrafi TA, Alqahtani HM, Kamal E, Hasan IH.   +5 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Natural products targeting the Nrf2 signaling pathway: potential targets and intervention strategies for the prevention and treatment of colorectal cancer. [PDF]

Front Pharmacol
Jiao M, Su J, Li P, Kong Q, Feng T, Kong W.   +5 more
europepmc   +1 more source

Clinical Relevance of BACH1 Expression in Non–Small Cell Lung Cancer

International Journal of Cancer, EarlyView.
ABSTRACT BTB and CNC homolog 1 (BACH1) is a redox‐sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance in non–small cell lung cancer (NSCLC) remain unclear.
Jing Liu, Marc A. Schneider, Julia Held, Sabine Wrenger, Wenzhang Si, Michael Allgaeuer, Florian Eichhorn, Sabina Janciauskiene   +7 more
wiley   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [PDF]

Adv Sci (Weinh)
Qiao M, Zhou L, Zhou M, Fang Y, Mai H, Cao L, Xu K, Sang Y, Chen M, Huang J, Huang P, Yan Z, Wang C, Dai Z, Huang D, He R, Pang L, Guo Y, Chew TG, Huang J.   +19 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Statin-Mediated Modulation of Nrf2 Signaling: Mechanisms and Therapeutic Implications in Atherosclerosis. [PDF]

Rev Cardiovasc Med
Marzoog BA, Kopylov P.
europepmc   +1 more source