Results 31 to 40 of about 9,804 (228)
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]
, 2014 In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V. +4 more
core +1 more source
The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization
Journal of General Virology, 2011 Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is a multi-functional protein that is expressed in basally phosphorylated (p56) and in hyperphosphorylated (p58) forms. NS5A phosphorylation has been implicated in regulating multiple aspects of HCV replication. We recently reported the identification of a class of compounds that potently inhibit
Dike, Qiu +13 more
openaire +2 more sources
Desirable Characteristics of Hepatitis C Treatment Regimens: A Review of What We Have and What We Need. [PDF]
, 2016 There have been dramatic advancements in the treatment of chronic hepatitis C (HCV) infection. This is largely due to the approval of several direct-acting antiviral agents (DAAs) from a variety of medication classes with novel mechanisms of action ...
Bidell, Monique R +4 more
core +2 more sources
Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core [PDF]
ACS Medicinal Chemistry Letters, 2013 Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity ...
Bae, IH +6 more
openaire +3 more sources
PLoS Pathogens, 2017 Hepatitis C virus (HCV) RNA is synthesized by the replicase complex (RC), a macromolecular assembly composed of viral non-structural proteins and cellular co-factors.
Tiffany Benzine +9 more
doaj +1 more source
Minimum target prices for production of direct acting antivirals and associated diagnostics to combat Hepatitis C Virus [PDF]
, 2014 Combinations of direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naïve patients. Mass treatment programs to cure HCV in developing countries are only feasible if the costs of treatment and laboratory ...
Cooke, GS +6 more
core +2 more sources
Management of direct antiviral agent failures [PDF]
Clinical and Molecular Hepatology, 2016 The current standard of care for patients with chronic hepatitis C virus (HCV) infection is a combination of direct-acting antiviral agents (DAAs). Most HCV patients treated with these drugs achieve viral elimination, but 1% to 15% fail to attain this ...
María Buti, Rafael Esteban
doaj +1 more source
Complete replication of hepatitis C virus in cell culture. [PDF]
, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R +10 more
core +1 more source
PLoS ONE, 2017 The objective was to develop a method of HCV genome sequencing that allowed simultaneous genotyping and NS5A inhibitor resistance profiling. In order to validate the use of a unique RT-PCR for genotypes 1-5, 142 plasma samples from patients infected with
Elisabeth Andre-Garnier +12 more
doaj +1 more source
Chinese Medical Journal, 2015 Background: It has been reported that several baseline polymorphisms of direct-acting antivirals (DAAs) agents resistance-associated variants (RAVs) would affect the treatment outcomes of patients chronically infected with hepatitis C virus (CHC).
Ye Wang +3 more
doaj +1 more source