Results 191 to 200 of about 355,709 (346)

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano   +6 more
wiley   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner   +7 more
wiley   +1 more source

RTOG 9705, a phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIA non-small cell lung cancer (NSCLC) patients — promising long term survival results [PDF]

open access: bronze, 2003
Mary V. Graham   +9 more
openalex   +1 more source

Clinical and economic impact of recurrence in unresected non-small cell lung cancer treated with primary stereotactic body radiotherapy: A real-world study using SEER-Medicare data. [PDF]

open access: yesJ Manag Care Spec Pharm
Rai P   +11 more
europepmc   +1 more source

Early pembrolizumab clearance as prognostic biomarker for non‐response in patients with advanced non‐small cell lung cancer

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Immune checkpoint inhibitors have improved survival rates in patients with advanced‐stage non‐small cell lung cancer; however, the majority obtain no long‐term benefits. This analysis derived from two prospective clinical studies indicates that lean body weight‐normalized clearance of pembrolizumab is a highly sensitive biomarker for the ...
Fenna de Vries   +36 more
wiley   +1 more source

Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Immune checkpoint inhibitors (ICIs) are effective against various cancers, but as more patients receive these therapies, more immune‐related adverse events (irAEs) emerge. Recent studies have suggested that ICIs are associated with an increase in pulmonary artery diameter and the ratio between pulmonary artery diameter and aortic diameter ...
Yao Xu   +11 more
wiley   +1 more source

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