Results 221 to 230 of about 278,336 (309)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Comparative efficacy and safety of first, second, and third-generation EGFR tyrosine kinase inhibitors in treatment-naïve EGFR-mutant advanced non-small cell lung cancer: a systematic review and network meta-analysis of randomized controlled trials. [PDF]

J Egypt Natl Canc Inst
Mahato S, Mudgal S, Singh H, Varikasuvu SR, Kumar H, Thankachan J, Kumar S.   +6 more
europepmc   +1 more source

Differential Transcriptome Analysis of Lung Squamous Cell Carcinoma Under Different RUNX3 Expression Patterns

Medicine Advances, EarlyView.
RUNX3 status in lung squamous cell carcinoma (LUSC) is associated with subtle gene‐level differences but reveals exploratory pathway‐level patterns, including epithelial differentiation, extracellular matrix remodeling, and hypoxia‐related programs. These findings generate testable hypotheses for RUNX3's biological role in LUSC.
Weibin Liu, Xiaobin Zheng, Jianqing Zheng, Yujie Deng, Bifen Huang, Weijin Xiao, Jiarong Zhang, Xuejin Zheng, Xinlong Zheng, Gen Lin, Xiaohui Chen   +10 more
wiley   +1 more source

National trends, variation and short-term outcomes in surgery for non-small cell lung cancer in England, 2015-2023: a population-based cohort study using linked national cancer registration and hospital administrative data. [PDF]

BMJ Open
Dixon LK, Cook S, Cook A, Thomas J, Boudour J, Chan F, Conibear J, West D, Navani N, Cromwell DA.   +9 more
europepmc   +1 more source

Large Language Model Benchmarks in Medical Tasks

Medicine Advances, EarlyView.
This survey provides a comprehensive review of benchmark datasets for evaluating large language models in medical tasks, spanning text, image, and multimodal modalities, and covering key resources including MIMIC‐III/IV, BioASQ, PubMedQA, and CheXpert.
Lawrence K. Q. Yan, Qian Niu, Ming Li, Yichao Zhang, Caitlyn Heqi Yin, Cheng Fei, Benji Peng, Ziqian Bi, Pohsun Feng, Keyu Chen, Tianyang Wang, Yunze Wang, Silin Chen, Ming Liu, Junyu Liu, Xinyuan Song, Riyang Bao, Zekun Jiang, Ziyuan Qin   +18 more
wiley   +1 more source

Correction: Case Report: Exceptional survival with immunotherapy in a patient with <i>EGFR</i> exon 20 insertion (p.S768_D770dup) and high PD-L1 expression. [PDF]

Front Immunol
Zhao S, Chen Y, Kuang M, Li Y.
europepmc   +1 more source

RETRACTION: Circular RNA_0001946 is Insufficiently Expressed in Tumor Tissues, While its Higher Expression Correlates With Less Lymph Node Metastasis, Lower TNM Stage, and Improved Prognosis in NSCLC Patients

Journal of Clinical Laboratory Analysis, EarlyView.
RETRACTION: M. Zhang, F. Wen, and K. Zhao, “Circular RNA_0001946 is Insufficiently Expressed in Tumor Tissues, While its Higher Expression Correlates With Less Lymph Node Metastasis, Lower TNM Stage, and Improved Prognosis in NSCLC Patients,” Journal of Clinical and Laboratory Analysis 35, no. 8 (2020): e23625, https://doi.org/10.1002/jcla.23625.
wiley   +1 more source

FOXD3 Is Functionally Linked to NF-κB Signaling in KRAS G12C-Mutant NSCLC Cells. [PDF]

Cells
Xu P, Peng J, Guo C, Liu Z, Cao Y, Sheng Q, Xu W, Li X.   +7 more
europepmc   +1 more source

First-Line Lorlatinib in Striatin-Anaplastic Lymphoma Kinase-Positive Lung Adenocarcinoma: A Case Report and Literature Review. [PDF]

Respirol Case Rep
Maebeya M, Tamura S, Shono T, Hoso T, Tatsuta H.   +4 more
europepmc   +1 more source

Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma

The Journal of Pathology, EarlyView.
Abstract Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct subtype of lung adenocarcinoma with unique clinicopathologic features; however, its histogenesis remains incompletely understood. Although mucinous metaplasia has been suspected as a precursor lesion, direct molecular evidence supporting this progression is limited. In this study,
Joon Young Park, Do Yeon Kim, Hyun Jung Lee, Jung Hee Lee, Hae Ryoun Park, Dong Hoon Shin   +5 more
wiley   +1 more source